@article { author = {Khalili, Mohsen and Zahedi, Elham and Narenjkar, Jamshid and Sanaie Rad, Ashkan}, title = {Ameliorative activity of co-administration of ketamine and ECT on depression like behaviors in depressed rats}, journal = {Journal of Basic and Clinical Pathophysiology}, volume = {6}, number = {1}, pages = {43-48}, year = {2018}, publisher = {Shahed University}, issn = {2322-1895}, eissn = {2345-4334}, doi = {10.22070/jbcp.2018.3005.1091}, abstract = {Background and Objective: Electroconvulsive therapy (ECT) is the end choice treatment for patients with major depressive disorder (MDD). Regarding researches that show NMDA receptor inactivation could yield the same results as anti-depressant drugs, however, the present study examined co-administration of ECT and ketamine (as NMDA antagonist) on depressed rat behaviors.   Materials and Methods: Fifty healthy adult male Wistar rats were divided into control (normal, no treatment) and CUMS induced depressed rats. The depressed animals were subdivided into 1- ECT, 2-ketamine, and 3- ECT + ketamine and 4- no treatment. We used sucrose preference, forced swimming, open field and elevated plus maze tests for evaluation of depression-related behavioral function. Results: Data analysis in CUMS depressed rats that treated with ketamine + ECT showed higher sucrose consumption in sucrose preference test, more immobility in forced swimming, and the vast activity in open field and plus maze tests. Conclusion: The behavioral analysis tests show that combination therapy with ketamine and electroconvulsive could markedly reduce depression and anxiolytic behaviors than ketamine or ECT treatment alone. }, keywords = {Ketamine,Electroconvulsive therapy,Depression}, url = {https://jbcp.shahed.ac.ir/article_625.html}, eprint = {https://jbcp.shahed.ac.ir/article_625_d034baf6587f69fcbe4ffd29dbe8e336.pdf} }