%0 Journal Article %T Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation %J Journal of Basic and Clinical Pathophysiology %I Shahed University %Z 2322-1895 %A Narenjkar, Jamshid %A Abyar, Zeinab %A Roghani, Mehrdad %D 2015 %\ 09/10/2015 %V 3 %N 2 %P 13-18 %! Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation %K Curcumin %K Diabetes mellitus %K Anti-nociceptive %K Formalin test %K Hot tail immersion test %K Paw pressure test %K Lipid peroxidation %K Inflammation %R 10.22070/jbcp.2015.226 %X Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. Materials and Methods: This study was conducted on 40 male rats that were divided into control, curcumin-treated control, diabetic, and curcumin-treated diabetic groups. The treatment groups received i.p. administration of curcumin at a dose of 50 mg/kg for 4 weeks. Finally, hyperalgesia were assessed using standard tests. Meanwhile, serum MDA and TNFa level was also measured. Results: Curcumin treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (pConclusion: Chronic administration of curcumin has anti-nociceptive property, partly via attenuation of lipid peroxidation and inflammatory processes. %U https://jbcp.shahed.ac.ir/article_226_bd1ededd585cb22c790fffde293bb498.pdf