%0 Journal Article %T Phytic Acid Mitigates Motor Asymmetry in Male Rat with Unilateral 6-Hydroxydopamine Striatal Lesion %J Journal of Basic and Clinical Pathophysiology %I Shahed University %Z 2322-1895 %A Rahmati, Batool %A Khalili, Mohsen %A Hamoleh-Shalali, Zohreh %A Roghani, Mehrdad %A Baluchnejadmojarad, Tourandokht %D 2015 %\ 09/10/2015 %V 3 %N 2 %P 25-28 %! Phytic Acid Mitigates Motor Asymmetry in Male Rat with Unilateral 6-Hydroxydopamine Striatal Lesion %K Phytic acid %K Parkinson’s disease %K 6-hydroxydopamine %K Motor asymmetry %R 10.22070/jbcp.2015.228 %X Background and Objective: Parkinson's disease (PD) is a movement disorder with debilitating symptoms. Available treatments for PD mainly include its symptomatic relief with no prevention of its progression. Due to the iron-chelating and antioxidant effect of phytic acid (PA), this study was conducted to assess its protective effect in 6-hydroxydopamine-induced model of PD in rat. Materials and Methods: Unilateral intrastriatal 6-OHDA-lesioned rats were daily pretreated with PA p.o. at a dose of 100 mg/kg for three days till 1 h pre-surgery. Apomorphine-induced rotations were counted at 1st week post-surgery. Results: A significant contralateral rotational behavior was observed in 6-OHDA-lesioned rats (pConclusion: These findings imply that pre-lesion PA treatment could attenuate motor asymmetry in experimental model of PD and this may be of benefit in lessening motor derangements in afflicted patients.  %U https://jbcp.shahed.ac.ir/article_228_bcabd8d43bb0e62cd165eaebd3953a7d.pdf