%0 Journal Article %T Dose-dependent effect of Hypericum perforatum extract on motor imbalance following intrastriatal injection of 6-hydroxydopamine in the rat %J Journal of Basic and Clinical Pathophysiology %I Shahed University %Z 2322-1895 %A Afshin-Majd, Siamak %A Khalili, Mohsen %A Kiasalari, Zahra %A Rahmati*, Batool %A Karami, Manijeh %A Ghaedi, Gholamhossein %A Baluchnejadmojarad, Tourandokht %A Roghani, Mehrdad %A Ansari, Fariba %D 2016 %\ 03/01/2016 %V 4 %N 1 %P 23-26 %! Dose-dependent effect of Hypericum perforatum extract on motor imbalance following intrastriatal injection of 6-hydroxydopamine in the rat %K Hypericum perforatum 6-hydroxydopamine Rotational behavior Motor imbalance Dose-dependent %R 10.22070/jbcp.2016.281 %X Background and Objective: Parkinson's disease (PD) is a neurodegenerative disease with selective damage of mesencephalic dopaminergic neurons. Due to the protective, anti-inflammatory, and antioxidant effect of Hypericum perforatum (HP), this study was undertaken to assess dose-dependent effect of HP hydroalcoholic extract on motor imbalance following intrastriatal injection of 6-hydroxydopamine in the rat. Materials and Methods: In this experimental research, male Wistar rats (n=35) were equally divided into sham, 6-hydroxydopamine (OHDA)-lesioned, and HP extract-treated lesion groups. Model of PD was induced by microinjecting 12.5 microgram of 6-OHDA dissolved in saline-ascorbate solution into the left striatum. Treated lesion groups received HP extract at doses of 50, 100, and 200 mg/kg/day p.o. started one week before the surgery for 1 week post-surgery. After 1 week, ipsilateral and contralateral rotations induced by apomorphine were counted and net scores were obtained. Results: In the 6-OHDA-lesioned group, the dopaminergic agonist apomorphine induced contralateral rotational behavior (PConclusion: Oral administration of HP extract at doses of 100 and 200 mg/kg could reduce motor imbalance and attenuate forced biased rotational behavior in 6-OHDA-induced model of PD. %U https://jbcp.shahed.ac.ir/article_281_2c31fddddc7f10b4db7068e3155c4d95.pdf