%0 Journal Article %T Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging %J Journal of Basic and Clinical Pathophysiology %I Shahed University %Z 2322-1895 %A Tayanloo-Beik, Akram %A Kiasalari, Zahra %A Roghani, Mehrdad %D 2022 %\ 06/29/2022 %V 10 %N 1 %P 45-49 %! Paeonol alleviates brain glucose hypometabolism in streptozotocin murine model of sporadic Alzheimer’s disease using microPET imaging %K Sporadic Alzheimer’s disease %K Streptozotocin %K Paeonol %K Brain glucose hypometabolism %K Positron emission tomography %R 10.22070/jbcp.2021.14670.1145 %X Background and Objective: Intracerebroventricular (ICV) injection of streptozotocin (STZ) in rodents causes a model of sporadic Alzheimer's disease (sAD) with development of insulin resistance and neuronal dysfunction. Paeonol is a phenolic agent with neuroprotective effect due to its anti-inflammatory and anti-oxidant effects. This study was conducted to assess its beneficial effect in prevention of brain glucose hypometabolism in ICV STZ rat model of sAD.Materials and Methods: STZ (3 mg/kg) was bilaterally injected ICV on days 0 and 2 using stereotaxic surgery and paeonol was orally given at two doses of 25 (low) or 100 (high) mg/kg from day 0 (post-surgery) till day 24 post-STZ. At the end of study, positron emission tomography (PET) imaging was employed with a micro-PET scanner through tail vein injection of 18FDG and brain to background ratio (BBR) was calculated.Results: ICV-STZ group had a significantly low BBR compared to sham group. In contrast, ICV-STZ group treated with paeonol at a dose of 100 mg/kg had a significantly higher BBR as compared to ICV-STZ group, clearly indicating attenuation of brain glucose hypometabolism. In addition, paeonol at a dose of 25 mg/kg did not significantly improve BBR in ICV-STZ group.Conclusion: In summary, these results revealed the beneficial dose-dependent effect of paeonol in amelioration of brain glucose hypometabolism in STZ-induced model of sAD.  %U https://jbcp.shahed.ac.ir/article_3808_c34fb1dbce5cdb1e82e42c2c5da11140.pdf