%0 Journal Article %T The effect of methadone and haloperidol combination on anxiety induced by morphine withdrawal in male mice %J Journal of Basic and Clinical Pathophysiology %I Shahed University %Z 2322-1895 %A Sanaie Rad, Ashkan %A Zahedi, Elham %A Ansari, Fariba %A Khalili, Mohsen %D 2017 %\ 03/01/2017 %V 5 %N 1 %P 19-26 %! The effect of methadone and haloperidol combination on anxiety induced by morphine withdrawal in male mice %K Morphine %K anxiety %K methadone %K haloperidol %K mice %R 10.22070/jbcp.2017.2267.1074 %X Background and Objective: Regarding inefficiency of common drugs used for alleviation of anxiety due to narcotics withdrawal, the present study was evaluated methadone and haloperidol co-drugs therapy on anxiety due to morphine withdrawal. Materials and Methods: Ninety eight NMRI male mice were divided into acute and chronic experimental groups. Then, each group was divided into 7 subgroups: saline, morphine (control), methadone, haloperidol, methadone+haloperidol, methadone+haloperidol with 2/1 and 1/2 ratio, respectively. Mice were addicted chronically (over 8 days) by receiving escalating doses of morphine and acute (morphine was applied only on 8th day) procedures. Anxiety was induced by naloxone application in addicted mice. Elevated plus-maze and open field tests were used for evaluation of anxiety. Results: Obtained data showed that in both chronic and acute groups, treatment with co-drugs methadone and haloperidol could markedly alleviate anxiety signs produced by interruption of morphine consumption. Conclusion: We found out that the anxiety as a major sign of morphine withdrawal sign could be diminished by methadone+haloperidol therapy versus drugs alone. %U https://jbcp.shahed.ac.ir/article_437_bd7cae62b030e797d82fce4aee560d82.pdf