ORIGINAL_ARTICLE
Selenium nanoparticles inclusion into chitosan hydrogels act as a chemical inducer for differentiation of PC12 cells into neuronal cells
Background and Objective: Biomaterials and nanomaterials have generated a great opportunity in regenerative medicine. Neurological disorders can result in permanent and severe derangement in motor and sensory functions. This study was conducted to examine the effects of selenium nanoparticles (Se NPs) as a chemical inducer for differentiation of PC12 cells into sympathetic-like neurons characterized by neurite outgrowth.Materials and Methods: Size, surface charge, the shape of Se NPs and the morphology of hydrogels were characterized by dynamic light scattering (DLS), zeta sizer, transmission electron microscopy (TEM) and scanning electron microscopy (SEM), respectively. DAPI staining, RT-PCR and western blot assays were used to evaluate cell attachment and mRNA and protein levels of neuronal markers, respectively.Results: The hydrodynamic size of Se NPs was about 33.55 nm and their surface charge was shifted from -24 to +3.4 mV. The morphological characterization demonstrated monodisperse spherical particles after coating with BSA. SEM images demonstrated that chitosan hydrogel containing Se NPs has suitable pore sizes for penetration of cells. DAPI staining and live/dead assay demonstrated the ability of cell attachment and biocompatibility of hydrogel, respectively. RT-PCR and western blot assays showed that neurite extension of differentiated PC12 cells can be linked to significantly increased mRNA levels of Map2, β-tubulin, increased protein levels of neurofilament-200 (NF200) as neuronal markers and decreased protein levels of ki67 protein as a proliferation marker.Conclusion: Collectively, our findings show that Se NPs can act as a chemical inducer for the differentiation of PC12 cells into sympathetic-like
https://jbcp.shahed.ac.ir/article_1179_b82c0eb05a26e7365fe8dd48c3286267.pdf
2020-06-01
1
8
10.22070/jbcp.2020.5077.1127
Selenium nanoparticles
Neuronal differentiation
Chitosan hydrogels
Nerve regeneration
Hamed
Amani
hamedamani2020@yahoo.com
1
Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Science, Tehran, Iran
AUTHOR
Hanif
Kazerooni
hanif.kazerooni@gmail.com
2
Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
AUTHOR
Hossein
Hassanpoor
hossein.hassanpoor@gmail.com
3
Department of Cognitive Science, Dade Pardazi, Shenakht Mehvar, Atynegar (DSA) Institute, Tehran, Iran
LEAD_AUTHOR
Ong W, Pinese C, Chew SY. Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries. Advanced Drug Delivery Reviews 2019.
1
Poplawski G, Ishikawa T, Brifault C, Lee‐Kubli C, Regestam R, Henry KW, et al. Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. Glia 2018;66(8):1577-90.
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Anderson MA, Burda JE, Ren Y, Ao Y, O’Shea TM, Kawaguchi R, et al. Astrocyte scar formation aids central nervous system axon regeneration. Nature 2016;532(7598):195.
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Bonfanti L. From hydra regeneration to human brain structural plasticity: a long trip through narrowing roads. The Scientific World Journal 2011;11:1270-99.
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Schuh CM, Day AG, Redl H, Phillips J. An optimized collagen-fibrin blend engineered neural tissue promotes peripheral nerve repair. Tissue Engineering Part A 2018;24(17-18):1332-40.
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Meyer C, Stenberg L, Gonzalez-Perez F, Wrobel S, Ronchi G, Udina E, et al. Chitosan-film enhanced chitosan nerve guides for long-distance regeneration of peripheral nerves. Biomaterials 2016;76:33-51.
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Santos D, Wieringa P, Moroni L, Navarro X, Valle JD. PEOT/PBT guides enhance nerve regeneration in long gap defects. Advanced Healthcare Materials 2017;6(3):1600298.
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Gu X, Ding F, Yang Y, Liu J. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Progress in Neurobiology 2011;93(2):204-30.
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Vishnoi T, Singh A, Teotia AK, Kumar A. Chitosan-gelatin-polypyrrole cryogel matrix for stem cell differentiation into neural lineage and sciatic nerve regeneration in peripheral nerve injury model. ACS Biomaterials Science & Engineering 2019.
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Dalamagkas K, Tsintou M, Seifalian A. Advances in peripheral nervous system regenerative therapeutic strategies: a biomaterials approach. Materials Science and Engineering: C 2016; 65:425-32.
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Bąk M, Gutkowska ON, Wagner E, Gosk J. The role of chitin and chitosan in peripheral nerve reconstruction. Polymers in Medicine 2017; 47(1):43-7.
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Zhao Y, Wang Y, Gong J, Yang L, Niu C, Ni X, et al. Chitosan degradation products facilitate peripheral nerve regeneration by improving macrophage-constructed microenvironments. Biomaterials 2017;134:64-77.
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Cardoso BR, Roberts BR, Bush AI, Hare DJ. Selenium, selenoproteins and neurodegenerative diseases. Metallomics 2015;7(8):1213-28.
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Flohé L. Selenium and human health: snapshots from the frontiers of selenium biomedicine. Selenium and tellurium chemistry: Springer; 2011: 285-302.
14
Zhang J, Zhou X, Yu Q, Yang L, Sun D, Zhou Y, et al. Epigallocatechin-3-gallate (EGCG)-stabilized selenium nanoparticles coated with Tet-1 peptide to reduce amyloid-β aggregation and cytotoxicity. ACS Applied Materials & Interfaces 2014;6(11):8475-87.
15
Zheng C, Wang J, Liu Y, Yu Q, Liu Y, Deng N, et al. Functional selenium nanoparticles enhanced stem cell osteoblastic differentiation through BMP signaling pathways. Advanced Functional Materials 2014;24(43):6872-83.
16
Mili B, Das K, Kumar A, Saxena A, Singh P, Ghosh S, et al. Preparation of NGF encapsulated chitosan nanoparticles and its evaluation on neuronal differentiation potentiality of canine mesenchymal stem cells. Journal of Materials Science: Materials in Medicine 2018;29(1):4.
17
Baniasadi H, SA AR, Mashayekhan S. Fabrication and characterization of conductive chitosan/gelatin-based scaffolds for nerve tissue engineering. International Journal of Biological Macromolecules 2015;74:360-6.
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Subhi H, Hakimi I, Jie NTL, Reza F, Husein A, Nurul AA. Effect of chitosan on antibacterial activity of gypsum-based biomaterial compared to two dental liners. Journal of International Oral Health 2019;11(3):118.
19
Vaz JM, Pezzoli D, Chevallier P, Campelo CS, Candiani G, Mantovani D. Antibacterial coatings based on chitosan for pharmaceutical and biomedical applications. Current Pharmaceutical Design 2018;24(8):866-85.
20
Liu W, Li X, Wong Y-S, Zheng W, Zhang Y, Cao W, et al. Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism. ACS Nano 2012;6(8):6578-91.
21
Sakr TM, Korany M, Katti KV. Selenium nanomaterials in biomedicine—An overview of new opportunities in nanomedicine of selenium. Journal of Drug Delivery Science and Technology 2018;46:223-33.
22
Kong H, Yang J, Zhang Y, Fang Y, Nishinari K, Phillips GO. Synthesis and antioxidant properties of gum arabic-stabilized selenium nanoparticles. International Journal of Biological Macromolecules 2014;65:155-62.
23
Cremonini E, Zonaro E, Donini M, Lampis S, Boaretti M, Dusi S, et al. Biogenic selenium nanoparticles: characterization, antimicrobial activity and effects on human dendritic cells and fibroblasts. Microbial Biotechnology 2016;9(6):758-71.
24
Menon S, KS SD, Santhiya R, Rajeshkumar S, Kumar V. Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism. Colloids and Surfaces B: Biointerfaces 2018;170:280-92.
25
Yu B, Zhang Y, Zheng W, Fan C, Chen T. Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles. Inorganic Chemistry 2012;51(16):8956-63.
26
Yang L, Sun J, Xie W, Liu Y, Liu J. Dual-functional selenium nanoparticles bind to and inhibit amyloid β fiber formation in Alzheimer's disease. Journal of Materials Chemistry B 2017;5(30):5954-67.
27
Tian L, Prabhakaran MP, Hu J, Chen M, Besenbacher F, Ramakrishna S. Synergistic effect of topography, surface chemistry and conductivity of the electrospun nanofibrous scaffold on cellular response of PC12 cells. Colloids and Surfaces B: Biointerfaces 2016;145:420-9.
28
Chen X, Wu Y, Ranjan VD, Zhang Y. Three-dimensional electrical conductive scaffold from biomaterial-based carbon microfiber sponge with bioinspired coating for cell proliferation and differentiation. Carbon 2018;134:174-82.
29
Li N, Zhang Q, Gao S, Song Q, Huang R, Wang L, et al. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Scientific Reports 2013;3:1604.
30
Greene LA, Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proceedings of the National Academy of Sciences 1976;73(7):2424-8.
31
Hu Y, Liu T, Li J, Mai F, Li J, Chen Y, et al. Selenium nanoparticles as new strategy to potentiate γδ T cell anti-tumor cytotoxicity through upregulation of tubulin-α acetylation. Biomaterials 2019;222:119397.
32
Ahmed NH, El-Batal AI, Barakat LA, Khirallah SM. Possibility of Selenium Nanoparticles Manufactured by Glycyrrhiza glabra Extract and γ-irradiation to Suppress the Growth of Murine Tumor. Journal of Advance Research in Pharmacy & Biological Science 2019;5(2):01-23.
33
ORIGINAL_ARTICLE
Antibacterial effects of methanolic and aqueous extracts of eight plants in traditional medicine
Background and Objective: Escherichia coli bacteria often causes infections in the gastrointestinal tract and other parts such as the urinary tract. Staphylococcus aureus is a common pathogen that causes infections in the skin, upper respiratory tract, and many parts of the body. In recent years, resistance to these bacteria has become one of the medical problems of antibiotics. Flowering herbs from the past are used to treat genital and gastrointestinal tract infections, and traditional herbal remedies are used to treat prostatic inflammation, gastric and intestinal ulcers, and lungs, kidneys and bladder problems. Hypericum perforatum is used to relieve the cough, symptoms of common cold, sputum, and healing wounds and injuries. Artemisia absinthium is beneficial for the treatment of arthritis, and inflammation of the spleen and hepatitis and the lavender plant is antiseptic. The aim of this study was to determine the antimicrobial effect of the extracts of these plants.Materials and Methods: In this study, the antimicrobial effects of aqueous and ethanolic extracts of the above-mentioned plants on standard bacteria were studied. Methanolic and aqueous extracts were performed using standard methods. Serial dilution of the extracts was prepared. The extracts were then concentrated in water bath. Determination of hypersensitivity was done by disc diffusion method for each extract and the findings were analyzed.Results: The results of this study showed that the alcoholic and aqueous extracts of Artemisia absinthium on Escherichia coli and Achilles millefolium aqueous extract on Staphylococcus aureus have the highest effect. The antimicrobial effect of the aqueous extract of Ruta graveolens and alcoholic extract of Artemisia absinthium was more than the others.Conclusion: The widespread use of antibiotics and drug resistance has led to more attention to medicinal plants. Some plants extracts have a significant antimicrobial effect. The plants studied in this study had an inhibitory effect on Escherichia coli and Staphylococcus aureus strains. It can be hoped that with further investigation of the various forms of the extracts, effective and safe drugs were obtained to control the bacteria.
https://jbcp.shahed.ac.ir/article_1180_fc01c43b852a774a38eb1235c9c1b89e.pdf
2020-06-01
9
15
10.22070/jbcp.2019.4535.1117
Escherichia coli
Staphylococcus aureus
Medicinal plants extracts
Antibacterial effects
Akbar
Sheykhani
1
Department of Microbiology, Medicine Faculty, Shahed University, Tehran, Iran
AUTHOR
Mohammad
Niakan
niakan@shahed.ac.ir
2
Department of Microbiology, Medicine Faculty, Shahed University, Tehran, Iran
LEAD_AUTHOR
Zahra
Mottaghian
3
Department of Microbiology, Medicine Faculty, Shahed University, Tehran, Iran
AUTHOR
Zahra
Salahi
4
Department of Microbiology, Medicine Faculty, Shahed University, Tehran, Iran
AUTHOR
De Biase D, Lund PA. The Escherichia coli Acid Stress Response and Its Significance for Pathogenesis. Advances in Applied Microbiology 2015;92:49-88.
1
Ferdosi-Shahandashti E, Javanian M, Moradian-Kouchaksaraei M, Yeganeh B, Bijani A, Motevaseli E, et al. Resistance patterns of Escherichia coli causing urinary tract infection. Caspian Journal of Internal Medicine 2015;6(3):148-51.
2
AthanasiosL I.Alvaro..Matthias H. Metabolic-flux dependent regulation of microbial physiology. Current Opinion in Microbiology 2018; 42:71-78
3
Diawara I, Bekhti K, Elhabchi D, Saile R, Elmdaghri N, Timinouni M, et al. Staphylococcus aureus nasal carriage in hemodialysis centers of Fez, Morocco. Iranian Journal of Microbiology 2014;6(3):175-83.
4
Akerele JO, Obasuyi O, Onyeagwara N, Ottih I. Methicillin-Resistant Staphylococcus aureus (MRSA):An Emerging Phenomenon among non-Hospitalized Otorhinolaryngological Patients in Benin City, Nigeria. West African Journal of Medicine 2014;33(4):276-9.
5
Solberg CO. Spread of Staphylococcus aureus in hospitals: causes and prevention. Scandinavian Journal of Infectious Diseases 2000;32(6):587-95.
6
AboAli, translated by Sherfkandi (AS)-The Rule. 2014; 2-Soroush-15th ed: 55-56.
7
The antibacterial and synergistic potential of some Palestinian plant extracts against multidrug resistant Staphylococcus aureus .Journal of Medicinal Plants Studies. Journal of Medicinal Plants Studies 2017; 5(2): 54-65.
8
Fonkeng L S, Mouokeu R S, Tume Ch, Njateng G S S, Kamcthueng M O, et al. Anti-Staphylococcus aureus activity of methanolic extracts of 12 plants used in Cameroonian folk medicine. BMC Research Notes 2015;8:710.
9
Biruhalem Taye, Mirutse Giday,Abebe Animut, and Jemal Seid .Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia. Asian Pacific Journal of Tropical Biomedicine 2011; 1(5): 370–375.
10
Mostaghim T, Afshar A , Mohammadpourfard I, Sayadi M , Rezaei M, Shariatifar N. Antibacterial Properties of Essential Oil of Heracleum persicum (Golpar) and Foodborne Pathogens. International Journal of Enteric Pathogens 2017;5(2): 41-44.
11
AboAli, translated by Sherfkandi (AS)-The Rule 2014; 54-55 2-Soroush-15th ed.
12
Jazini, Promoting the medicine properties of plants. 12-Kankavosh Publishers- first ed 2010.
13
Naber KG, Alidzhanov Zh F. [Are there alternatives to antimicrobial therapy and prophylaxis of uncomplicated urinary tract infections?]. Urologiia 2014(6):5-8, 10-3.
14
Leonard S F, Raymond S M , Christopher T, Guy S S. Njateng M, et al. Anti-Staphylococcus aureus activity of methanol extracts of 12 plants used in Cameroonian folk medicine ، BMC Research Notes 2015; 8:710.
15
KianMehr, Hormozdyar- Iran herbs 2014;13-14 first ed.
16
Adock, James, teacher translators- Z, MohagheghZadeh A. Shamse Ardakani- Plants Culture Journal 2013;704-707. -Rah-e-Kamal Publishers, Polo- 2th ed.
17
Ahani S, Saeidi S, Javadian F, Akbarizadeh Z and Ali Sobhanizade. Investigation the Antibacterial Effects of Plant Extract on Pseudomonas aeruginosa and Escherichia coli. . International Journal of Infection 2018; 5(2):32-39
18
Antibiotic therapy for acute uncomplicated pyelonephritis in women. Take resistance into account. Prescrire International 2014;23(155):296-300.
19
Bonten MJ, Bergmans DC, Speijer H, Stobberingh EE. Characteristics of polyclonal endemicity of Pseudomonas aeruginosa colonization in intensive care units. Implications for infection control. American Journal of Respiratory and Critical Care Medicine 1999;160(4):1212-9.
20
AboAli, translated by Sherfkandi (AS)-The Rule 2014; 2-Soroush-15th ed:183- 2014
21
Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, et al. Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs. Asian Pacific Journal of Tropical Medicine 2013;6(9):673-81.
22
Khan UA, Rahman H, Qasim M, Hussain A, Azizllah A, Murad W, et al. Alkanna tinctoria leaves extracts: a prospective remedy against multidrug resistant human pathogenic bacteria. BMC Complementary and Alternative Medicine 2015;15:127.
23
Kohler CD, Dobrindt U. What defines extraintestinal pathogenic Escherichia coli? International Journal of Medical Microbiology. 2011;301(8):642-7.
24
ORIGINAL_ARTICLE
Isolation and determination of antibiotic resistance patterns of urinary tract infections pathogens in patients who referred to Pol-e Dokhtar medical centers during 2016-2018
Background: Urinary tract infection (UTI) is one of the most common human bacterial infections. The frequent use of antibiotics is associated with increased resistance of many bacterial agents to the treatment.Materials and Methods: A total of 9456 urine specimens were collected from patients referring to Pol-e Dokhtar health centers. All urine samples were inoculated on blood agar plates (BAP) and eosin methylene blue (EMB) agar. Those specimens positive for selected pathogen were finally identified. The antimicrobial susceptibility and resistance patterns of the UTI pathogens to common antibiotics were determined using disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines.Results: Out of 9456 investigated urine samples, 1036 samples (10.95%) were positive, of which 823 samples (79.4%) belonged to female subjects and 213 samples (20.6%) belonged to males. The most common identified urine tract pathogens were Escherichia coli (69.4%), Staphylococcus epidermidis (15.15%) and Staphylococcus aureus (7.05%). Also, co-trimoxazole (sulfamethoxazole/trimethoprim) displayed the highest antibiotic resistance (58.1%) and nitrofurantoin (90.1%) and gentamicin (88%) were shown to be the most frequent cause of sensitivity.Conclusion: The findings of our study demonstrate that E. coli is the most common UTI pathogen. Given the high antibiotic resistance of co-trimoxazole, it is recommended to avoid indiscriminate consumption of this antibiotic and perform antibiogram tests for the treatment of UTIs.
https://jbcp.shahed.ac.ir/article_1181_eddef0c846b18f0462c103cb3ceb8a89.pdf
2020-06-01
16
20
10.22070/jbcp.2020.4849.1122
Urinary tract infection
Antibiotic resistance patterns
Escherichia coli
Zahra
Babaei
za.babaei66@gmail.com
1
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
AUTHOR
Nikou
Bahrami
nikou.bahrami@yahoo.com
2
Department of Biology, Faculity of science, Shahid Chamran University of Ahvaz, Iran
AUTHOR
Atefeh
Kamali
atikamali6868@gmail.com
3
Department of Microbiology, Kerman Branch, Islamic Azad university, Kerman, Iran
AUTHOR
Iman
Pouladi
imanpouladi96a@gmail.com
4
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
LEAD_AUTHOR
Madaen SK, Stakhri R, Ghaniafshord H, Fazl-Farhadi V. The Prevalence and Type of Urinary Tract Infection in Patients with Urethral Catheter in Urology Department of Imam Reza Hospital. Journal of Tabriz University of Medical Sciences 2016; 38(4):72-75.
1
Baghani Aval HR, Ekrami Toroghi M, Haghighi F, Tabarraie Y. Common Bacterial Factors of Urinary Tract Infections and Determining their Antibiotic Resistance in Hospitalized and out Patients Referred to the Vase’ee Hospital in Sabzevar in 2016. Journal of Sabzevar University of Medical Sciences 2018; 25 (5): 687-693
2
Ahanjan M, Haghshenas MR, Naghshvar F, Bairamvand E. Prevalance of Urinary Tract Infection in Patients Attending Imam Khomeini Hospital, Sari, 2010-2011. Journal of Mazandaran University of Medical Sciences 2013; 23(Supple 1): 82-86 (Persian).
3
Ramirez-Castillo FY, Moreno-Flores AC, Avelar-Gonzalez FJ, Maraquez-Diaz F, Harel J, Guerrero-Barrera AL. An evaluation of multidrug-resistant Escherichia coli isolates in urinary tract infections from Aguascalientes, Mexico: cross- sectional study. Annals of Clinical Microbiology and Antimicrobials 2018;17(1):34.
4
Mohammadi S, Ramazanzadeh R, Zandi S, Rouhi S, Mohammadi B. Isolation and antibiotic resistance pattern determination of bacteria causing urinary tract infections in patients referred to Sanandaj`s Tohid Hospital, 2013-2014. Journal of Kurdistan University of Medical Sciences 2015;16(50):55-62.
5
Jarsiah P, Alizadeh A, Mehdizadeh E, Ataee R, Khanalipour N. Evaluation of Antibiotic Resistance Model of Escherichia Coli in Urine Culture Samples at Kian Hospital Lab in Tehran, 2011-2012. Journal of Mazandaran University of Medical Sciences 2014; 24: 78-83 (Persian).
6
Rasoulzadeh Bidgoli M, Golmakani N, Ebrahimzadeh Zagmi S, Nasiri S. Cranberry Effects on Prevention of Urinary Tract Infection. Journal of Student Research Committee Sabzevar University of Medical Sciاence. 2017;22(41): 16-22 .
7
Barari Sawadkouhi R, Sorkhi H, Pournasrollah M, Bijani A, Babazadeh N, Baleghi Damavand S. Antibiotic Resistance of Bacteria Causing Urinary Tract Infections in Children Hospitalized in Amirkola Children Hospital during 2010-2011. Journal of Babol University of Medical Sciences 2013; 15(5): 89-94 .
8
Heidari-Soureshjani E, Heidari M, Doosti A. Epidemiology of urinary tract infection and antibiotic resistance pattern of Escherichia coli in patients referred to Imam Ali hospital in Farokhshahr, Chaharmahal va Bakhtiari, Iran. Journal of Shahrekord University of Medical Sciences 2013; 15(2): 9-15 .
9
Mahmoudi H, Emadmomtaz H, Karimitabar Z, Emam AH, Khanali S, Alikhani MY. Prevalence of asymptomatic urinary tract infection in primary school children of Hamadan City and drug resistance of isolated microorganisms in 2014. Pajouhan Scientific Journal 2015;13(3): 8- 14 .
10
Mohammadi S,Argha K, Akhzarifar N, Panahi Z, Pakzad I, Sayehmiri K. Analysis of Antibiotic Resistance in Bacterial Strains Isolated from Urine Cultures of Patients Referred to Clinical Laboratories of Ilam City during 2012. Journal of Ilam University of Medical Sciences 2016.;24(2) .
11
Etebarzadeh Z, Oshaghi M, Mozafari NA. Evaluation of relationship between phylogenetic typing and antibiotic resistance of uropathogenic Escherichia coli. Journal of Microbial World 2012;3(3) .
12
Raeeszadeh M, Ahmadi E, Shafiee M. Identification of the antibiotic resistance patterns in bacteria isolated from urinary tract infections in patients admitted to Shahid Ghazi Hospital Sanandaj in the first 6 months of 2014. Razi Journal of Medical Sciences 2016;23(147) .
13
Hejazi F, Ahanjan M, Akha O, Salehiyan M. Phenotypic Study of Urinary Tract Infection Producing Bacteria and Antibiotic Resistance Pattern in Diabetic Patients. Journal of Mazandaran University of Medical Sciences 2018; 28 (163): 38-46 (Persian)
14
Abedi Samakoosh M, Aghaei N, Babamahmodi F,Dawodi AR. Frequency and Pattern of Urinary Pathogens and Their Antibiotic Resistance in Patients with Urinary Tract Infection. Journal of Mazandaran University of Medical Sciences 2015; 25(131): 155-158 (Persian).
15
Mojabi SM, Ranjbar R. The Frequency of Escherichia coli Strain Isolates Causing Urinary Tract Infections in the presence of Pathogenic Aerobactin Genes. Journal of Babol University of Medical Sciences 2015;17(5):31-6.
16
Klingeberg A, Noll I, Willrich N, Feig M, Emrich D, Zill E, et al. Antibiotic-Resistant Escherichia coli in Uncomplicated Community-Acquired Urinary Tract Infection. Deutsches Ärzteblatt International 2018;115(29-30): 494- 500 .
17
Asafo-Adjei K, Mensah JE, Labi AK, Dayie NTKD, Donkor ES. Urinary Tract Infections among Bladder Outlet obstruction patients in Accra, Ghana: Aetiology, Antibiotic Resistance, and Risk Factors. Diseases 2018;6(3):65.
18
Erdem I, Kara Ali R, Ardic E, Elbasan Omar S, Mutlu R, Topkaya AE. Community-acquired Lower Urinary Tract Infections: Etiology, Antimicrobial, and Treatment Results in Femal Patients. Journal of Global Infectious Diseases 2018;10(3): 129- 132 .
19
Moulana Z, Asgharpour F, Ramezani T. Frequency of the Bacterial Causing Agents in Urinary Tract Infection and Antibiotic Pattern Samples Sent to Razi Laboratory, Babol 2008-2009. Journal of Rafsanjan University of Medical Sciences 2013; 12(6): 489-494. [Farsi]
20
Guidoni EB, Berezin EN, Nigro S, Santiago NA, Benini V, Toporovski J. Antibiotic resistance patterns of pediatric community-acquired urinary infections. Brazilian Journal of Infectious Diseases 2008;12(4): 321- 3.
21
ORIGINAL_ARTICLE
Behavioral function improvement of prefrontal cortex in treated depressed rats by ECT and ketamine
Background and Objective: Depression is one of the most prevalent mental disorders. Electroconvulsive Therapy (ECT) is one of the effective methods for treatment of depression. Regarding the stimulatory effect of glutaminergic system on the progression of depression, the effect of ketamine as one of the most important inhibitors of this system has been investigated on the effectiveness of ECT. Given the fundamental role of pre-frontal cortex on changing the mood of depression-related behaviors in depressed patients, the effects of ketamine with ECT on this cortex were taken into account in this study.Materials and Methods: For this purpose, 50 male rats were used. Animals were randomly divided into five equal groups, and except the control group, the other ones were depressed by CUMS method. Then, three groups of depressed rats were treated in different ways (ECT, ketamine, and combined ECT and ketamine). Finally, behavioral parameters were measured.Results: The combination of ketamine and ECT could reduce prefrontal depression like behaviors by testing of: sucrose intake increased, the total immobility rate also decreased and open field behaviors increased.Conclusion: According to this study, the modification of behavioral parameters in rats treated with ECT and ketamine indicates the specific effect of electroconvulsive and ketamine therapy in modifying the mood and depression behaviors and behavioral test are showing the alleviation of depression signs. Electroconvulsive therapy in depressed rats with ketamine injection is recommended.
https://jbcp.shahed.ac.ir/article_1182_e962e52441ded7f09b7b487e2d32a98c.pdf
2020-06-01
21
27
10.22070/jbcp.2020.5002.1126
Depression
Ketamine
Electroconvulsive therapy
Rat
Zeinab
Naseri
zeinab_naseri@yahoo.com
1
Department of Physiology, School of Medicine, Shahed Univercity,Tehran, Iran
LEAD_AUTHOR
Mohsen
Khalili
najafabady@yahoo.com
2
Department of Physiology, School of Medicine, Shahed Univercity,Tehran, Iran
AUTHOR
Keyvan
Daneshi
keyvandaneshy@yahoo.com
3
Azad University Central Tehran Branch, Tehran, Iran
AUTHOR
Sagha F, Malmir H, Saneei P, Milajerdi A, Larijani B, Esmaillzadeh A. Fruit and vegetable consumption and risk of depression : accumulative evidence from an updated systematic review and meta-analysis of epidemiological studies. British Journal of Nutrition 2018; 119(10):1087-1101.
1
Zou L, Yeung A , Li Ch, Wei G X, Chen K W, et al. Effects of Meditative Movements on Major Depressive Disorder : A Systematic Review and Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine 2018;1;7(8):195.
2
Mitchell N D, Baker G B. An update on the role of glutamate in the pathophysiology of depression. Acta Psychiatrica Scandinavica 2010; 122(3):192-210.
3
Chavez-Castillo M, Victoria N, Nava M, Ortega a. Depression as a Neuroendocrine Disorder : Emerging Neuropsychopharmacological Approaches beyond Monoamines. Advances in Pharmacological Sciences 2019(1):1-20.
4
Ronald D. Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections,” Dialogues in Clinical Neuroscience 2014; 16(1):11-27.
5
Ratajczak P, Kus K, Zaprutko T, Szczepański M, Rusowicz S, Nowakowska E. Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats. Acta Neurobiologiae Experimentalis 2019; 79(1):13–24.
6
Suchet D. Khanzode, Ganesh N. Dakhale, Shruti S. Khanzode, Anand Saoji & R. Palasodkar, “Oxidative damage and major depression : the potential antioxidant action of selective serotonin re-uptake inhibitors Oxidative damage and major depression : the potential antioxidant action of selective serotonin. Redox Report 2003; 8(6):365-70.
7
Lopresti A L, Maker G L, Hood S D, Drummond P D. A review of peripheral biomarkers in major depression : The potential of in fl ammatory and oxidative stress biomarkers. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2014;48:102-11.
8
Hillhouse T M, Porter J H. A brief history of the development of antidepressant drugs: From monoamines to glutamateic. Experimental and Clinical Psychopharmacology 2015;23(1):1-21.
9
Friedman M A, Detweiler-Bedell J B, Leventhal H E, Horne R, Keitner G I, et al. Combined Psychotherapy and Pharmacotherapy for the Treatment of Major Depressive Disorder. Clinical Psychology: Science and Practice 2004; 1(1):47–68.
10
Fajemiroye J O, Silva D M , Oliveira D M, Costa E A. Treatment of anxiety and depression : medicinal plants in retrospect. Fundamental & Clinical Pharmacology 2016;30(3):198-215.
11
Kheradmand E, Hajizadeh Moghaddam A, Zare M. Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer’s disease. Biomedicine & Pharmacotherapy 2018; 97:1096–1101.
12
Ishola I O, Jacinta A A, Adeyem O O. Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice : role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF. Metabolic Brain Disease 2019;34(4):979-989.
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Antkiewicz-Michaluk L, Wasik A, Mozdzen E, Romanska I, Michaluk J. Antidepressant-like Effect of Tetrahydroisoquinoline Amines in the Animal Model of Depressive Disorder Induced by Repeated Administration of a Low Dose of Reserpine : Behavioral and Neurochemical Studies in the Rat. Neurotoxicity Research 2014;26(1):85-98.
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22
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23
ORIGINAL_ARTICLE
The effect of nobiletin on performance of rats in forced swimming and elevated plus maze tests in intranigral lipopolysaccharide rat model of Parkinson's disease
Background and Objective: Anti-inflammatory property of nobiletin (NOB) is proven and neuroinflammation is involved in triggering and progression of neurodegenerative disorder such as Parkinson's disease (PD). PD is a neurodegenerative disorder characterized by motor and non-motor features including psychiatric symptoms such as depression and anxiety. The purpose of this study to investigate whether oral nobiletin administration at a dose of 10 mg/kg has the ability to alleviate non-motor behavioural changes including depression and anxiety-like behaviors in LPS-induced model of PD in rat.Materials and Methods: For this purpose, 32 male Wistar rats (195-245 g) were divided into four groups (n=8) as follows: Sham-operated group, nobiletin-treated sham-operated group (sham+NOB), lesion group (LPS) and nobiletin-treated lesion group (LPS+NOB). LPS (5 μg/kg) rat was unilaterally injected into the SN of rat brains through standard stereotaxis, according to the atlas of Paxinos and Watson (to generate a neuroinflammatory model of PD), with or without NOB (10 mg/kg administrated daily for 1 week after surgery, via gavage). Behavioral assessment was carried out one week after surgery by assessment of performance in forced swimming and elevated plus maze tests.Results: NOB-treated LPS group showed significant decrease in immobility time and insignificant increase in the percentage of open arm spending time as compared with LPS group which demonstrate the anti-depressant like effect of NOB in inflammatory model of PD in rats.Conclusion: Taken together, this study demonstrated that nobiletin as an anxiolytic and anti-depressive agent in the LPS-induced rat model of Parkinson’s disease.
https://jbcp.shahed.ac.ir/article_1183_7fd3447214a961f3f48adc9e91c079c2.pdf
2020-06-01
28
34
10.22070/jbcp.2020.4355.1115
Parkinson’s disease
Nobiletin
Neuroinflammation
Behavioral changes
Lipopolysaccharide
Maryam
Khorasani
mk@yahoo.com
1
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
AUTHOR
Zahra
Kiasalari
kiasalari@yahoo.com
2
Neurophysiology Research Center, Shahed University, Tehran, Iran
AUTHOR
Reihane
Ghasemi
rgh@gmail.com
3
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
AUTHOR
Marzieh
Fakour
mf@yahoo.com
4
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
AUTHOR
Sedigheh
Keshtkar
sk@gmail.com
5
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
AUTHOR
Mehrdad
Roghani
mehjour@yahoo.com
6
Neurophysiology Research Center, Shahed University, Tehran, Iran
LEAD_AUTHOR
Braak H, Del Tredici K, Rüb U, De Vos RA, Steur ENJ, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiology of Aging 2003;24(2):197-211.
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54
ORIGINAL_ARTICLE
Ethanol impairs memory by reducing the synaptic connection of the hippocampal spatial neurons
Background and Objective: Ethanol has undesirable effects on memory and synaptic communication. However, its impact on the learned spatial memory is unclear. We investigated the damaging effects of ethanol on place neurons of rat’s hippocampal CA1.Materials and Methods: Sixty four male Wistar rats (250 g) were administered high (1-8 g/kg) or low (0.05-0.1 g/kg) doses of ethanol intraperitoneally (i.p.) and tested (10 min) for the novelty-seeking behavior using the place conditioning box. Sniffing, rearing, grooming, and compartment entering was compared between the first and the last stage, during which the animals had accessibility to the whole device. During the acquisition phase, the rats daily received ethanol (i.p.) and confined in one side of the device for 40 min. The control group solely received saline (1 ml/kg, i.p.). The achievements were analyzed by ANOVA under α = 0.05.Results: The ethanol-acquired animals with the high doses did not recall the information of the familiarization day and displayed a high tendency toward the non-confined side of the box. The rats also showed a reduction in place neuron synaptic strands.Conclusion: Ethanol disrupts spatial memory and also diminishes CA1 place neuron’s fibers.
https://jbcp.shahed.ac.ir/article_1184_4443975d4952add2219ea431f0e494d5.pdf
2020-06-01
35
41
10.22070/jbcp.2020.5249.1129
Ethanol
Acquisition
Novelty-seeking behavior
CA1
Place neuron
Samira
Geravand
samira.geravand@gmail.com
1
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
AUTHOR
Manizheh
Karami
karami@shahed.ac.ir
2
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
LEAD_AUTHOR
Tolman EC. Cognitive maps in rats and men. Psychological Review 1948; 55: 189-208.
1
O’Keefe J, Nadel L. The Hippocampus as a Cognitive Map. Oxford University Press, Walton Street, Oxford OX2 6DP 1978.
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Okada K, Okaichi H. Functional differentiation and cooperation among the hippocampal subregions in rats to effect spatial memory processes. Behavioural Brain Research 2009; 200(1): 181-191.
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20
ORIGINAL_ARTICLE
The effects of swimming exercise and Nepeta menthoides on depression and anxiety induced by reserpine
Background and Objective: Physical activity has long been associated with mental health. Nepeta menthoides is a native Iranian herb recently acknowledged for its anti-depressant properties. This study attempted to determine and compare the effects of swimming exercise and Nepeta menthoides on reserpine-induced depression in rats.Materials and Methods: Male rats (n=80) were assigned to 8 groups: 1-Saline, 2-Reserpine (0.2 mg/kg, i.p. for 14 days) 3-Swimmig Exercise( 30 min swimming sessions daily for 2 weeks ) 4-Nepeta (200 mg/kg), 5-Reserpine+Nepeta, 6-Reserpine+Swimming exercise, 7-Reserpine+Nepeta+Swimming exercise, 8-Reserpine+Fluoxetine, Finally, the behavioral tests including sucrose preference, elevated plus maze and open field were performed.Results: Obtained data showed that depressed rats which were treated with Nepeta, exercise or both of them expressed higher preference for sucrose relative to reserpine group and their locomotor activity was also significantly improved. However, combined Nepeta+Exercise could not significantly antagonize the effect of reserpine on time spent in the open arms of elevated plus maze, but Nepeta in particular displayed marked anti-anxiety effect.Conclusion: Combined treatment with Nepeta+exercise as the same as only Nepeta or exercise was able to alleviate anhedonia and low activity in depressed rats. Nevertheless, Nepeta alone could significantly improve reserpine-induced anxiety.
https://jbcp.shahed.ac.ir/article_1185_9d29be03161352c9bc28588337990853.pdf
2020-06-01
42
46
10.22070/jbcp.2020.4949.1123
Depression
Reserpine
Swimming Exercise
Nepeta menthoides
Faezeh
Rezaei
fayzhr01@gmail.com
1
Department of Physiology, Faculty of Medicine, Shahed University, Tehran, Iran
AUTHOR
Batoul
Rahmati
batrahmati@yahoo.com
2
Neurophysiology Research Center, Shahed University, Tehran, Iran
LEAD_AUTHOR
Maryam
Malakian
m.malakian@yahoo.com
3
Department of Physiology, Faculty of Medicine, Shahed University, Tehran, Iran
AUTHOR
Mohsen
Khalili
najafabady@yahoo.com
4
Neurophysiology Research Center, Shahed University, Tehran, Iran
AUTHOR
Mahdi
Alizadeh
mehdi.alizadeh@shahed.ac.ir
5
Neurophysiology Research Center, Shahed University, Tehran, Iran
AUTHOR
Sinanović O, Hudić J, Zukić S, Kapidžić A, Zonić L, Vidović M. Depression and dementia in Parkinson’s disease. Acta clinica Croatica 2015;54(1.):73-5.
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Thachil A, Mohan R, Bhugra D. The evidence base of complementary and alternative therapies in depression. Journal of Affective Disorders 2007;97(1-3):23-35.
4
Archer T, Josefsson T, Lindwall M. Effects of physical exercise on depressive symptoms and biomarkers in depression. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 2014;13(10):1640-53.
5
Petzinger GM, Holschneider D, Fisher B, McEwen S, Kintz N, Halliday M, et al. The effects of exercise on dopamine neurotransmission in Parkinson’s disease: targeting neuroplasticity to modulate basal ganglia circuitry. Brain Plasticity 2015;1(1):29-39.
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Liu W, Sheng H, Xu Y, Liu Y, Lu J, Ni X. Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation. Behavioural Brain Research 2013;242:110-6.
8
Woost L, Bazin P-L, Taubert M, Trampel R, Tardif CL, Garthe A, et al. Physical exercise and spatial training: a longitudinal study of effects on cognition, growth factors, and hippocampal plasticity. Scientific Reports 2018;8(1):4239.
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Asadi Balsin Sharif Abadi S, Nasri S, Amin G, Bidaran S. Anti-inflammatory and anti-nociceptive effects of hydroalchoholic extract of Nepeta menthoides on pain in aerial parts in male mice. Journal of Jahrom University of Medical Sciences 2013;11(3):1-9.
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Kolouri S, Firoozabadi A, Salehi A, Zarshenas MM, Dastgheib SA, Heydari M, et al. Nepeta menthoides Boiss. & Buhse freeze-dried aqueous extract versus sertraline in the treatment of major depression: A double blind randomized controlled trial. Complementary Therapies in Medicine 2016;26:164-70.
12
Antkiewicz-Michaluk L, Wąsik A, Możdżeń E, Romańska I, Michaluk J. Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat. Neurotoxicity Research 2014;26(1):85-98.
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