ORIGINAL_ARTICLE
Anti-depressant effect of hesperidin in ovariectomized mice: possible involvement of dopaminergic and serotoninergic systems
Objective: This study aimed to determine anti-depressant effect of hesperidin in ovariectomized mice and its possible interaction with dopaminergic and serotoninergic systems.
Materials and Methods: In experiment 1, mice were kept as control and sham groups, ovariectomized (OVX), OVX+ hesperidin (12.5 mg/kg), OVX+ hesperidin (25 mg/kg) and OVX+hesperidin (50 mg/kg). In experiment 2, mice were kept as control and sham, OVX, OVX+hesperidin (50 mg/kg), OVX+dopamine (25 mg/kg) and OVX+co-injection of hesperidin and dopamine. Experiments 3-5 were like experiment 2, except 6-OHDA (dopamine inhibitor, 100 mg/kg), fluoxetine (selective serotonin reuptake inhibitor, 5 mg/kg) and cyproheptadine (serotonergic receptor antagonist, 4 mg/kg) was injected instead of dopamine. Then, forced swimming test (FST), tail suspension test (TST) and open field test (OFT) were done. Also, serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS) levels were determined.
Results: According to the results, OVX increased immobility time in FST and TST tests as compared to control group (P<0.05). Hesperidin (50 mg/kg) decreased immobility time as compared to OVX group (P<0.05). Co-injection of hesperidin+dopamine decreased immobility time in TST and FST and increased number of crossing in OFT (P<0.05). Co-injection of hesperidin+6-OHDA significantly decreased antidepressant activity of the hesperidin on immobility time and decreased positive effect of the hesperidin on the number of crossing (P<0.05). Co-injection of hesperidin+Fluoxetine significantly amplified antidepressant activity of the hesperidin on immobility time and number of crossing (P<0.05). Co-injection of hesperidin+cyproheptadine decreased antidepressant activity of hesperidin on immobility time (P<0.05). Hesperidin (12.5, 25 and 50 mg/kg) decreased the MDA, while increased SOD and GPx levels in OVX mice (P<0.05).
Conclusion: It is assumed that antidepressant activity of hesperidin is mediated via dopaminergic and serotoninergic receptors in OVX mice.
https://jbcp.shahed.ac.ir/article_3292_648faa92454fe82cee60fd7fb8568fff.pdf
2021-05-01
1
15
10.22070/jbcp.2021.13851.1138
Anti-depressant
Hesperidin
Serotoninergic
Dopaminergic
Ghazal
Hosseini
hosseini@yahoo.com
1
Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Alireza
Jahandideh
jahandideh@yahoo.com
2
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Shahin
Hassanpour
hassanpour.shahin@gmail.com
3
Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
LEAD_AUTHOR
Ghasem
Akbari
akari@yahoo.com
4
Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
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46
ORIGINAL_ARTICLE
Heart rate variability as a predictive factor for coronary artery disease
Background and Objective: Heart rate variability (HRV) is the amount of heart rate fluctuations around the mean heart rate and can be used as a mirror of the cardiorespiratory control system. It is a valuable tool to investigate the sympathetic and parasympathetic functions of the autonomic nervous system. This variation during respiration is called respiratory sinus arrhythmia (RSA). RSA reflects heart rate control system, especially a cardiac parasympathetic activity which can be evaluated by some proper tests such as standing test. Researches show HRV alters among patients with coronary artery diseases (CAD). Materials and Methods: In this study, we intended to calculate amount of HRV in patients with chest pain before diagnostic exercise stress test (EST) and to compare the obtained results with EST results. 66 (19 women and 47 men) with chest pain. Volunteers and unknown CAD referred for EST with a mean age of 50 years were participated in this study. Each volunteer underwent deep breathing (6 breaths/minute) and standing up tests prior to EST for HRV measurements. Results: There was less variation in heart rate during both deep breathing and standing up tests in patients with positive result of EST than in patients with negative result of EST. Conclusion: Our study suggests that HRV is depressed in individuals who have unknown coronary artery disease with an immediate positive EST result.
https://jbcp.shahed.ac.ir/article_3293_4e9e2d2a513aae83c83770f9043b4927.pdf
2021-06-28
16
22
10.22070/jbcp.2021.14122.1139
Heart rate variability
respiratory sinus arrhythmia
coronary artery diseases
Ravieh
Golchoobian
rgolchoobian@yahoo.com
1
Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
LEAD_AUTHOR
Syed Abbas
Foroutan
abfor@sbmu.ac.ir
2
Department of Physiology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Maryam
Mihammadian
maryam.mohammadian2008@yahoo.com
3
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
1. Acharya UR, Joseph KP, Kannathal N, Lim CM, Suri JS. Heart rate variability: a review. Medical and Biological Engineering and Computing 2006; 44(12):1031-51. doi: 10.1007/s11517-006-0119-0.
1
2. Li H-R, Lu T-M, Cheng H-M, Lu D-Y, Chiou C-W, Chuang S-Y, et al. Additive value of heart rate variability in predicting obstructive coronary artery disease beyond Framingham risk. Circulation Journal 2016; 80(2):494-501. doi: 10.1253/circj.CJ-15-0588.
2
3. Katona PG, Jih F. Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control. Journal of Applied Physiology 1975; 39(5):801-5. doi: 10.1152/jappl.1975.39.5.801.
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4. Stålberg EV, Nogués MA. Automatic analysis of heart rate variation: I. Method and reference values in healthy controls. Muscle & Nerve 1989; 12(12):993-1000. doi: 10.1002/mus.880121207.
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5. Airaksinen K, Ikäheimo M, Linnaluoto M, Niemelä M, Takkunen J. Impaired vagal heart rate control in coronary artery disease. Heart. 1987; 58(6):592-7. doi: 10.1136/hrt.58.6.592.
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8. Malliani A, Pagani M, Lombardi F, Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 1991; 84(2):482-92. doi: 10.1161/01.cir.84.2.482.
8
9. Hayano J, Yuda E. Pitfalls of assessment of autonomic function by heart rate variability. Journal of physiological Anthropology 2019;38(1):3. https://doi.org/10.1186/s40101-019-0193-2.
9
10. Shields RW. Heart rate variability with deep breathing as a clinical test of cardiovagal function. Cleveland Clinic Journal of Medicine 2009; 76 Suppl 2:S37-40. doi: 10.3949/ccjm.76.s2.08.
10
11. Huikuri HV, Mäkikallio TH. Heart rate variability in ischemic heart disease. Autonomic Neuroscience 2001; 90(1-2):95-101. doi: 10.1016/S1566-0702(01)00273-9.
11
12. Hayano J, Sakakibara Y, Yamada M, Ohte N, Fujinami T, Yokoyama K, et al. Decreased magnitude of heart rate spectral components in coronary artery disease. Its relation to angiographic severity. Circulation 1990; 81(4):1217-24. doi: 10.1161/01.cir.81.4.1217.
12
13. Minisi AJ, Thames MD. Effect of chronic myocardial infarction on vagal cardiopulmonary baroreflex. Circulation Research 1989; 65(2):396-405. doi: 10.1161/01.res.65.2.396.
13
14. Huikuri HV, Jokinen V, Syvänne M, Nieminen MS, Airaksinen KJ, Ikäheimo MJ, et al. Heart rate variability and progression of coronary atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35(1):1. doi: 10.1161/ATV.0000000000000016.
14
15. La Rovere MT, Bigger Jr JT, Marcus FI, Mortara A, Schwartz PJ, Investigators A. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. The Lancet 1998; 351(9101):478-84. doi: 10.1016/s0140-6736(97)11144-8.
15
16. Pfeifer MA, Cook D, Brodsky J, Tice D, Reenan A, Swedine S, et al. Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man. Diabetes 1982; 31(4 Pt 1):339-45. doi: 10.2337/diab.31.4.339.
16
17. Villareal RP, Liu BC, Massumi A. Heart rate variability and cardiovascular mortality. Current atherosclerosis Reports 2002; 4(2):120-7. doi: 10.1007/s11883-002-0035-1.
17
18. Singh JP, Larson MG, O’Donnell CJ, Wilson PF, Tsuji H, Lloyd-Jones DM, et al. Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). The American Journal of Cardiology 2000; 86(3):309-12. doi: 10.1016/s0002-9149(00)00920-6.
18
19. Goldenberg I, Goldkorn R, Shlomo N, Einhorn M, Levitan J, Kuperstein R, et al. Heart rate variability for risk assessment of myocardial ischemia in patients without known coronary artery disease: The HRV‐DETECT (heart rate variability for the detection of myocardial ischemia) study. Journal of the American Heart Association 2019; 8(24):e014540. doi: 10.1161/JAHA.119.014540.
19
20. Ge D, Srinivasan N, Krishnan SM. Cardiac arrhythmia classification using autoregressive modeling. Biomedical Engineering Online 2002; 1:5. doi: 10.1186/1475-925x-1-5.
20
ORIGINAL_ARTICLE
Assessment of antioxidant and cutaneous wound healing effects of Ornithogalum cuspidatum hydroalcoholic extract in male Wistar rats
Background and Objective: Ornithogalum cuspidatum is a medicinal plant in Iranian traditional medicine that has several pharmacological effects. Due to strong antioxidant and anti-inflammatory activities of this plant, the current study was designed to evaluate wound healing activity of O. cuspidatum on cutaneous wounds in Wistar rats.
Materials and Methods: A full-thickness excisional wounds was induced on the back of 50 Wistar rats. The animals were randomly divided into five groups, including control, basal cream, phenytoin, O. cuspidatum 5%, and O. cuspidatum 10%. Five animals of each group were euthanized at 10 and 20 days post-injury (DPI) and wounds were assessed through gross and histopathological analyses. Also, hydroxyproline content and MDA, NO and TOS concentrations were determined.
Results: Treated animals with O. cuspidatum showed a significant reduction in the wound surface area at 10 and 20 dpi. Moreover, treatment with this plant reduced the number of lymphocytes and macrophages, increased the number of fibroblasts at the earlier stages and enhanced number of fibrocytes at the later stages of wound healing. O. cuspidatum significantly improved re-epithelialization and epithelial formation, enhanced hydroxyproline content and thereby maturity of the collagen fibers. Also, O. cuspidatum significantly reduced MDA, NO and TOS concentration as oxidant status in granulation tissue.
Conclusion: The present study demonstrated that application of hydroethanolic extract of O. cuspidatum promoted wound healing due to increased re-epithelialization and collagen deposition in wound tissue and also induction of considerable wound contraction, so it can be considered as a therapeutic agent for wound healing.
https://jbcp.shahed.ac.ir/article_3294_20807d42c7d6156da2b6ca0db9cf35c5.pdf
2021-06-28
23
32
10.22070/jbcp.2021.14242.1140
Ornithogalum cuspidatum
antioxidant
Wound healing
Fatemeh
Hoseinpour
fhossainpour@yahoo.com
1
Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
LEAD_AUTHOR
Mohammad
Hashemnia
m.hashemnia@razi.ac.ir
2
Department of Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
AUTHOR
Hadi
Cheraghi
dr.hadi.cheraghi@gmail.com
3
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
AUTHOR
Reza
Safikhani
rezasafikhanitabriz22@gmail.com
4
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
AUTHOR
Tahereh
Sheikhi
tsheikhi731@gmail.com
5
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
AUTHOR
Zahra
Hasani
shiny1376@yahoo.com
6
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
AUTHOR
Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacology Physiology Journal 2014; 27(6):303-10. doi: 10.1159/000357477.
1
Raghow R. The role of extracellular matrix in postinflammatory wound healing and fibrosis. Official Publication of the Federation of American Societies for expericmental Biology Journal 1994; 8(11):823-31. doi: 10.1096/fasebj.8.11.8070631.
2
Sandhya SS, Kumar S, Vinod KR, Banji D, Kumar K. Plants as Potent antidiabetic and Wound healing agents-a Review. Hygeia- Journal for Drugs and Medicines 2011; 3: 11-19. Corpus ID: 76374697
3
Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Frontiers in Bioscience 2004; 9:283-9. doi: 10.2741/1184.
4
Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through angiogenesis and by mobilizing and recruiting bone marrow-derived cells. American Journal of Pathology 2004; 164(6): 1935-1947. doi: 10.1016/S0002-9440(10)63754-6.
5
Asadi H, Orangi M, Shanehbandi D, Babaloo Z, Delazar A, Mohammadnejad L, et al. Methanolic Fractions of Ornithogalum cuspidatum Induce Apoptosis in PC-3 Prostate Cancer Cell Line and WEHI-164 Fibrosarcoma Cancer Cell Line. Advanced Pharmaceutical Bulletin 2014; 4: 455-458. doi: 10.5681/apb.2014.067
6
Chen R, Men F, Liu Z, Chen R, Zhang M. Antitumor activities of different fractions of polysaccharide purified from Ornithogalum caudatum Ait. Carbohydrate Polymers 2010; 80(3):845-851. https://doi.org/10.1016/j.carbpol.2009.12.042
7
Delazar A, Nazifi E, Movafeghi A, Nazemiyeh H, Hemmati S, Lutfun, N, et al. Analyses of phytosterols and free radical scavengers in the bulbs of Ornithogalum cuspidatum Bertol. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 2010; 9(2): 87-92.
8
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Makasci AA, Mammadov R, Dusen O, Isik H. Antimicrobial and antioxidant activities of medicinal plant species Ornithogalum alpigenum stapf. from Turkey. Journal of Medicinal Plants Research 2010; 4(16):1637-1642.
10
Nazifi E, Movafeghi A, Nazemiyeh H, Asnaashari S, Bamdad Moghadam S, Delazar A. Phytochemical analysis of essential oils from different plant parts of Ornithogalum cuspidatum Bertol. Pharmaceutical Sciences 2010; 16(1):37-46.
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Dastan D, Aliahmadi A. Antioxidant and antibacterial studies on different extracts of Ornithogalum cuspidatum Bertol from Iran. Biological Forum- An International Journal 2015; 7(2): 1072-1075.
12
Hashemnia M, Javdani M, Nikousefat Z, Hoseinpour F, Kakaei S. Evaluation of the wound healing activity of methanolic extract of Tragopogon porrifolius in rat. Research Opinions in Animal & Veterinary Sciences 2014; 4(8):446-452. Corpus ID: 54223272
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Ghashghaei A, Hashemnia M, Nikousefat Z, Zangeneh MM, Zangeneh A. Wound healing potential of methanolic extract of Scrophularia striata in rats. Pharmaceutical Sciences 2017; 23(4): 256-263. doi: 10.15171/PS.2017.38
14
Oryan A, Tabatabaieinaieni A, Moshiri A, Mohammadalipoor A, Tabandeh MR. Modulation of cutaneous wound healing by Silymarin in rats. Journal of Wound Care 2012; 21(9):457-64. doi: 10.12968/jowc.2012.21.9.457.
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Nagori BP, Solanki R. Role of medicinal plants in wound healing. Research Journal of Medicinal Plants 2011; 5(4): 392-405. doi: 10.3923/rjmp.2011.392.405
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Rosique RG, Rosique MJ, Farina Junior JA. Curbing inflammation in skin wound healing: a review. International Journal of Inflammation 2015:316235. doi: 10.1155/2015/316235.
17
Yadav E, Singh D, Yadav P, Verma A. Antioxidant and anti-inflammatory properties of Prosopis cineraria based phenolic rich ointment in wound healing. Biomedicine & Pharmacotherapy 2018; 108:1572-1583. doi: 10.1016/j.biopha.2018.09.180.
18
Hyun Ko U, Choi J, Choung J, Moon S, Shin JH. Physicochemically tuned myofibroblasts for wound healing sterategy. Scientific Reports 2019; 9(1):16070. doi: 10.1038/s41598-019-52523-9.
19
Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biology 2020; 10(9):200223. doi: 10.1098/rsob.200223.
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Caetano GF, Fronza M, Leite MN, Gomez A, Cipriani Frade MA. Comparison of collagen content in skin wounds evaluated by biochemical assay and by computer-aided histomorphometric analysis. Pharmaceutical Biology 2016; 54(11):2555-2559. doi: 10.3109/13880209.2016.1170861
21
Parmar KM, Shende PR, Katare N, Dhobi M, Prasad SK. Wound healing potential of Solanum xanthocarpum in streptozotocin-induced diabetic rats. Journal of Pharmacy and Pharmacology 2018; 70(10):1389-1400. doi: 10.1111/jphp.12975.
22
Cianciosi D, Forbes-Hernandez TY, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna PP, et al. Phenolic compounds in honey and their associated health benefits: A review. Molecules 2018; 23(9):2322. doi: 10.3390/molecules23092322.
23
Kundu A, Ghosh A, Singh NK, Singh GK, Seth A, Maurya SK, et al. Wound healing activity of the ethanol root extract and polyphenolic rich fraction from Potentilla fulgens. Pharmaceutical Biology 2016; 54(11):2383-2393. doi: 10.3109/13880209.2016.1157192.
24
Gallily R, Yekhtin Zh, Ondrej Hanus L. The anti-inflammatory properties of terpenoids from Cannabis. Cannabis and Cannabinoid Research 2018; 3(1): 282-290.
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Prakash V. Terpenoids as source of anti-inflammatory compounds. Asian Journal of Pharmaceutical and Clinical Research 2017; 10(3): 68-76. doi:10.22159/ajpcr.2017.v10i3.16435
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Elmann A, Mordechay S, Rindner M, Ravid U. Antineuroinflammatory effects of geranium oil in microglial cells. Journal of Functional Foods 2010; 2(1): 17-22. https://doi.org/10.1016/j.jff.2009.12.001
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Yadav E, Singh D, Yadav P, Verma A. Attenuation of dermal wounds via downregulating oxidative stress and inflammatory markers by protocatechuic acid rich nbutanol fraction of Trianthema portulacastrum Linn. in wistar albino rats. Biomedicine & Pharmacotherapy 2017; 96:86-97. doi: 10.1016/j.biopha.2017.09.125..
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Marrocco I, Altieri F, Peluso I. Measurement and clinical significance of biomarkers of oxidative stress in humans. Oxidative Medicine and Cellular Longevity 2017:6501046. doi: 10.1155/2017/6501046.
29
Ibrahim N, Wong SK, Mohamed IN, Mohamed N, Chin KY, Ima-Nirwana S, et al. Wound healing properties of selected natural products. International Journal of Environmental Research and Public Health 2018; 15(11): 2360. doi: 10.3390/ijerph15112360
30
ORIGINAL_ARTICLE
Down-regulation of insulin substrate receptor 1 and 2 in the liver may be a mechanism for insulin resistance during testosterone deprivation
Background and Objective: Type 2 diabetes is a global concern worldwide. Despite extensive studies on the physiological effects of diabetes on the testicular functions, the impact of testosterone deficiency on the glucose homeostasis remains to be clarified. This study was designed to investigate the effects of testosterone deprivation and its replacement with testosterone enanthate on the molecular mechanisms of insulin signaling pathway in the liver of rats.
Materials and Methods: We first established a rat model of testosterone deficiency by castration (CAS-S). Subsequently, the castrated rats were administrated by subcutaneous injection of testosterone (CAS-T). Thereafter, fasting blood glucose (FBG), insulin, and homeostasis model-insulin resistance (HOMA-IR) level was assessed. The testosterone and insulin levels were further analyzed by ELISA. The mRNA expression of insulin receptor (IR)-β, insulin receptor-substrate (IRS)1 and 2 as well as glucose transporter (GLUT) 2 in the liver was analyzed by q-RT-PCR assay.
Results: Our data showed that testosterone deprivation significantly increases FBG and HOMA-IR and down-regulates IRS-1 and IRS-2 mRNA expression in the liver. However, the mRNA expression of GLUT2 and IR-β was not affected. We also found that testosterone administration could improve the liver insulin resistance.
Conclusion: These findings suggested that testosterone deprivation can impact insulin signaling in the liver via suppressing expression of IRS-1 and IRS-2 mRNA and treatment with testosterone can improve the insulin resistance in the castrated rats. Further experimental and clinical pathways are needed to be assessed for clinical application of our finding.
https://jbcp.shahed.ac.ir/article_3299_1ac196a3e2472f5e0b503b7415a21dd9.pdf
2021-06-28
23
40
10.22070/jbcp.2021.14471.1142
Androgen
Hepatic insulin resistance
Diabetes
IRS 1 and 2
Glucose transporter 2
Mahnaz
Ghowsi
ghowsi.mahnaz@gmail.com
1
Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran
LEAD_AUTHOR
Sajjad
Sisakhtnezhad
sajjadsisakhtnezhad@gmail.com
2
Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran
AUTHOR
Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J. Epidemiology of type 2 diabetes–global burden of disease and forecasted trends. Journal of Epidemiology and Global Health 2020; 10(1):107-111. doi: 10.2991/jegh.k.191028.001.
1
Xu W, Morford J, Mauvais-Jarvis F. Emerging role of testosterone in pancreatic β cell function and insulin secretion. Journal of Endocrinology 2019;240(3):R97-R105.
2
Inaba M, Otani Y, Nishimura K, Takaha N, Okuyama A, Koga M, et al. Marked hyperglycemia after androgen-deprivation therapy for prostate cancer and usefulness of pioglitazone for its treatment. Metabolism 2005; 54(1):55-9. doi: 10.1016/j.metabol.2004.07.010.
3
Keating NL, O'Malley AJ, Freedland SJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer. Journal of the National Cancer Institute 2010; 102(1):39-46. doi: 10.1093/jnci/djp404.
4
Cheruiyot I, Olabu B, Kamau M, Ongeti K, Mandela P. Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism. Anatomy & Cell Biology 2018; 51(4):284-291. doi: 10.5115/acb.2018.51.4.284
5
Liao N, Zheng Y, Xie H, Zhao B, Zeng Y, Liu X, et al. Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats. Stem Cell Research & Therapy 2017; 8(1):286. doi: 10.1186/s13287-017-0743-7.
6
Kubota N, Kubota T, Kajiwara E, Iwamura T, Kumagai H, Watanabe T, et al. Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity. Nature Communications 2016; 7:12977. doi: 10.1038/ncomms12977.
7
Xing L-J, Zhang L, Liu T, Hua Y-Q, Zheng P-Y, Ji G. Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver. European Journal of Pharmacology 2011; 668(3):467-71. doi: 10.1016/j.ejphar.2011.07.036.
8
Previs SF, Withers DJ, Ren J-M, White MF, Shulman GI. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. Journal of Biological Chemistry 2000; 275(50):38990-4. doi: 10.1074/jbc.M006490200.
9
Kiani F, Sayehmiri F, Hasanpour Dehkordi A, Motedayen M. Surveying the relationship between Gly1057Asp polymorphism of IRS-2 gene and susceptibility to type 2 diabetes; a systematic review and meta-analysis study. Journal of Renal Injury Prevention 2019;8(4) 263-270. doi: 10.15171/jrip.2019.50
10
Schattner A, Katz-Porat B-S, Gindin Y, Geltner D. Cyproterone-induced hyperosmolar hyperglycemia. Drug Intelligence & Clinical Pharmacy 1988; 22(7-8):632-3. doi: 10.1177/106002808802200728
11
Jones TH, Arver S, Behre HM, Buvat J, Meuleman E, Moncada I, et al. Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study). Diabetes Care 2011; 34(4):828-37. doi: 10.2337/dc10-1233
12
Grossmann M, Hoermann R, Wittert G, Yeap BB. Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: a systematic review and meta‐analysis of randomized controlled clinical trials. Clinical Endocrinology 2015; 83(3):344-51. doi: 10.1111/cen.12664.
13
Xia F, Xu X, Zhai H, Meng Y, Zhang H, Du S, et al. Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male rats. Reproductive Biology and Endocrinology 2013; 11:106. doi: 10.1186/1477-7827-11-106
14
Chin K-Y, Ima-Nirwana S. The effects of testosterone deficiency and its replacement on inflammatory markers in rats: a pilot study. International Journal of Endocrinology and Metabolism 2017;15(1)e43053. doi: 10.5812/ijem.43053
15
16. Aref A-BM, Ahmed OM, Ali LA, Semmler M. Maternal rat diabetes mellitus deleteriously affects insulin sensitivity and Beta-cell function in the offspring. Journal of diabetes Research 2013:429154. doi: 10.1155/2013/429154.
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Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C T method. Nature Protocols 2008; 3(6):1101-8. doi: 10.1038/nprot.2008.73.
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Vanderschueren D, Jans I, Van Herck E, Moermans K, Verhaeghe J, Bouillon R. Time-related increase of biochemical markers of bone turnover in androgen-deficient male rats. Bone and Mineral 1994; 26(2):123-31. doi: 10.1016/s0169-6009(08)80057-8.
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Christoffersen B, Raun K, Svendsen O, Fledelius C, Golozoubova V. Evalution of the castrated male Sprague–Dawley rat as a model of the metabolic syndrome and type 2 diabetes. International Journal of Obesity 2006; 30(8):1288-97. doi: 10.1038/sj.ijo.0803261.
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Dimitriadis GK, Randeva HS, Aftab S, Ali A, Hattersley JG, Pandey S, et al. Metabolic phenotype of male obesity-related secondary hypogonadism pre-replacement and post-replacement therapy with intra-muscular testosterone undecanoate therapy. Endocrine 2018; 60(1):175-184. doi: 10.1007/s12020-017-1516-x.
20
Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Molecular Cell 2000;6(1):87-97. PMID: 10949030
21
Kawaguchi T, Taniguchi E, Itou M, Sakata M, Sumie S, Sata M. Insulin resistance and chronic liver disease. World Journal of Hepatology 2011; 3(5):99-107. doi: 10.4254/wjh.v3.i5.99.
22
Xie Z, Hao H, Tong C, Cheng Y, Liu J, Pang Y, et al. Human umbilical cord‐derived mesenchymal stem cells elicit macrophages into an anti‐inflammatory phenotype to alleviate insulin resistance in type 2 diabetic rats. Stem cells 2016; 34(3):627-39. doi: 10.1002/stem.2238.
23
Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 2014; 510(7503):84-91. doi: 10.1038/nature13478.
24
Baranova A, Tran T, Birerdinc A, Younossi Z. Systematic review: association of polycystic ovary syndrome with metabolic syndrome and non‐alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics 2011;33(7):801-14. doi: 10.1111/j.1365-2036.2011.04579.x.
25
Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL. Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proceedings of the National Academy of Sciences 2001;98(7):3756-61. doi: 10.1073/pnas.071054598.
26
Hirashima Y, Tsuruzoe K, Kodama S, Igata M, Toyonaga T, Ueki K, et al. Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. Journal of Endocrinology 2003;179(2):253-66. doi: 10.1677/joe.0.1790253.
27
Stanley J. The regulation of glucose production: The role of liver glycogen and gluconeogenesis in the liver and kidney cortex. British Journal of Anaesthesia 1981;53(2):137-46. doi: 10.1093/bja/53.2.137.
28
ORIGINAL_ARTICLE
The effect of l-arginine on estrogen level and ovarian cyst in aged rats with polycystic ovaries
Background and Objective: Menopause in women is associated with many complications that most of them are related to the decrease of estrogen levels in this period. Treatment with high doses of estrogen is common but has side effects. In this study, the effect of l-arginine administration on the level of this hormone in elderly rats was investigated. Materials and Methods: Elderly Wistar rats were first studied with the help of Papanicolaou test to identify the stage of female sexual cycle. If confirmed to have diestrus phase, the rats were randomly classified into the following groups: control (saline 1 ml/kg, i.p.) and l-arginine group (5, 25, and 50 mg/kg). They were injected saline or l-arginine over a period of three to nine days. At the end, the rats were anesthetized by an i.p. injection of ketamine 100 mg/kg and xylazine 20 mg/kg and the blood samples were collected and the estrogen levels were measured with ELISA kit. The rats’ ovaries and uteri were also biometrically examined and fixed in the formalin. They were stained by H&E method and the number of cysts in the ovaries were counted. Data were analyzed by the ANOVA. Results: L-arginine at all doses (5-50 mg/kg) during all injection periods from three to nine days significantly increased the estrogen levels, but prominently reduced the ovarian cysts at the lowest dose (5 mg/kg). Conclusion: Low doses of l-arginine over short periods of time can relieve menopausal problems including estrogen levels and ovarian status, probably by the modulator nitric oxide.
https://jbcp.shahed.ac.ir/article_3296_64d704de3cd8b4119c556fa095f5c8f5.pdf
2021-06-28
41
46
10.22070/jbcp.2021.14488.1143
Menopause
Nitric oxide
Elderly
Fatemeh
Lakzaei
lakzaei.fateme@gmail.com
1
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
AUTHOR
Manizheh
Karami
karamip14@gmail.com
2
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
LEAD_AUTHOR
Mohammadreza
Jalali Nadoushan
jalalinadooshan@yahoo.com
3
Department of Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
AUTHOR
1. Speroff L, Fritz M. Clinical Gynecology endocrinology and infertility. 2nd ed. Williams & Wilkins 2005; 21-24.
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2. Shifren JI, Schiff I. Berek & Novak’s gynecology, 14th ed. Lippincott Williams & Wilkins 2007; 324-338.
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3. Gibbs R, Karlan B, Heny A. Danforth obstetrics and gynecology.10th ed. Lippincott Williams & Wilkins 2008; 725-740.
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4. Rabiee M, Dawati A, Zafarqandi N. Comparison of follicle-stimulating hormone sensitivity and vaginal acidity in the diagnosis of menopause, serum estradiol levels and related symptoms. Journal of Shahid Sadoughi University of Medical Sciences and Health Services, Yazd. 2011; 19(2):72-165.doi:10.5001/omj.2010.4
4
5. Kim S-M, Kim S-E, Lee D-Y, Choi D. Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women. Scientific Reports. 2021;11(1):3585. doi: 10.1038/s41598-021-81201-y.
5
6. Burger HG. Physiology and endocrinology of the menopause. Medicine. 2006;1(34):27-30
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7. Burger HG, Dudley EC, Robertson DM, Dennerstein L. Hormonal changes in the menopause transition. Recent Progress in Hormone Research. 2002;57:257-75. doi: 10.1210/rp.57.1.257.
7
8. Kazemzadeh R, Nikjou R, Rostamnegad M, Norouzi H. Effect of lavender aromatherapy on menopause hot flushing: a crossover randomized clinical trial. Journal of the Chinese Medical Association. 2016;79(9):489-92. doi: 10.1016/j.jcma.2016.01.020.
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9. Lindsay R. The menopause and osteoporosis. Obstetrics & Gynecology. 1996;87(2 Suppl):16S-19S. doi: 10.1016/0029-7844(95)00430-0.
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10. Sarkar M, Wolf MG. Simple ovarian cysts in postmenopausal women: scope of conservative management. European Journal of Obstetrics & Gynecology and Reproductive Biology 2012;162(1):75-8. doi: 10.1016/j.ejogrb.2011.12.034.
10
11. Park J, Kim TH, Lee HH, Lee W, Chung SH. Ovarian rete cyst in a post-menopausal woman: a case report. The Journal of Korean Society of Menopause. 2012;18(1):67-69.https://doi.org/10.6118/jksm.2012.18.1.67
11
12. Darblade B, Pendaries C, Krust A, Dupont S, Fouque MJ, Rami J,et al. Estradiol alters nitric oxide production in the mouse aorta through the α-, but not β-, estrogen receptor. Circulation Research. 2002;90(4):413-9. doi: 10.1161/hh0402.105096.
12
13. Tsuda K, Kinoshita Y, Nishio I. Synergistic role of progesterone and nitric oxide in the regulation of membrane fluidity of erythrocytes in humans: an electron paramagnetic resonance investigation. American Journal of Hypertension. 2002;15(8):702-8. doi: 10.1016/s0895-7061(02)02965-5.
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14. Tousoulis D, Kampoli AM, Tentolouris Nikolaos Papageorgiou C, Stefanadis C. The role of nitric oxide on endothelial function. Current Vascular Pharmacology. 2012;10(1):4-18. doi: 10.2174/157016112798829760.
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15. Yallampalli C, Byam-Smith M, Nelson SO, Garfield RE. Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus. Endocrinology. 1994134(4):1971-4 doi: 10.1210/endo.134.4.8137765.
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16. Gol A, Sofiabadi M, Abbasnejad M, Parvizi MR. The Regulatory Effect of Female Sex Steroid Hormones on Nitric Oxid Production. Journal of Rafsanjan University of Medical Sciences 2003;2(3):124-30.
16
17. Gol A, Sofiabadi M, Abbasnejad M, Parvizi MR. The Regulatory Effect of Female Sex Steroid Hormones on Nitric Oxid Production. Journal of Rafsanjan University of Medical Sciences 2003;2(3):124-30.
17
18. Gore AC, Yeung G, Morrison JH, Oung T. Neuroendocrine aging in the female rat: the changing relationship of hypothalamic gonadotropin-releasing hormone neurons and N-methyl-D-aspartate receptors. Endocrinology 2000;141(12):4757-67. doi: 10.1210/endo.141.12.7841.
18
19. Martin CJ, Watson RR, Preedy VR, editors. Nutrition and diet in menopause. Edition: 1stPublisher: Humana PressEditor: Hollins Martin, C.J., Watson, R.R., Preedy, V.R. (Eds.).ISBN: ISBN 978-1-62703-372-5.
19
20. Borrow AP, Cameron NM. Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2014;54:13-25. doi: 10.1016/j.pnpbp.2014.05.009.
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21. Horst GJT. Estrogen in the limbic system. Vitamins & Hormones 2010;82:319-38. doi: 10.1016/S0083-6729(10)82017-5.
21
22. Veerus P, Hovi SL, Sevón T, Hunter M, Hemminki E. The effect of hormone therapy on women's quality of life in the first year of the Estonian Postmenopausal Hormone Therapy trial. BMC Research Notes 2012;5:176. doi: 10.1186/1756-0500-5-176.
22
23. Khan A, Fortier M. Menopause and osteoporosis. Journal of Obstetrics and Gynaecology Canada 2014; 36(9):839-840. doi: 10.1016/S1701-2163(15)30489-8.
23
24. Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A. Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women. Health Care for Women International 2014;35(1):87-99. doi: 10.1080/07399332.2013.770001.
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25. Panay N, Hamoda H, Arya R, Savvas M. The 2013 British menopause society & women’s health concern recommendations on hormone replacement therapy. Menopause International 2013;19(2):59-68. doi: 10.1177/1754045313489645.
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26. Salvemini D, Ischiropoulos H, Cuzzocrea S. Roles of nitric oxide and superoxide in inflammation. Methods in molecular biology 2003:225:291-303. doi: 10.1385/1-59259-374-7:291.
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27. Cella M, Farina MG, Dominguez Rubio AP, Di Girolamo G, Ribeiro ML, Franchi AM. Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour. British Journal of Pharmacology 2010;161(4):844-55. doi: 10.1111/j.1476-5381.2010.00911.x.
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28. Tamanini C, Basini G, Grasselli F, Tirelli M. Nitric oxide and the ovary. Journal of Animal Science 2003;81(14_suppl_2):E1-7.
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30. Olson LM, Jones-Burton CM, Jablonka-Shariff AL. Nitric oxide decreases estradiol synthesis of rat luteinized ovarian cells: possible role for nitric oxide in functional luteal regression. Endocrinology 1996;137(8):3531-9. doi: 10.1210/endo.137.8.8754783.
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31. Fatemeh Lakzaei, Manizheh Karami, Mohammadreza Jalali Nadoushan, Fatemeh Hassani. Opposite effect of naloxone on infertility induced by nitric oxide system in an animal model of polycystic ovary. Daneshvar Medicine 2014; 21(110):85-94.
31
1. Speroff L, Fritz M. Clinical Gynecology endocrinology and infertility. 2nd ed. Williams & Wilkins 2005; 21-24.
32
2. Shifren JI, Schiff I. Berek & Novak’s gynecology, 14th ed. Lippincott Williams & Wilkins 2007; 324-338.
33
3. Gibbs R, Karlan B, Heny A. Danforth obstetrics and gynecology.10th ed. Lippincott Williams & Wilkins 2008; 725-740.
34
4. Rabiee M, Dawati A, Zafarqandi N. Comparison of follicle-stimulating hormone sensitivity and vaginal acidity in the diagnosis of menopause, serum estradiol levels and related symptoms. Journal of Shahid Sadoughi University of Medical Sciences and Health Services, Yazd. 2011; 19(2):72-165.doi:10.5001/omj.2010.4
35
5.
36
Kim S-M, Kim S-E, Lee D-Y, Choi D. Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women. Scientific Reports. 2021;11(1):3585. doi: 10.1038/s41598-021-81201-y.
37
6. Burger HG. Physiology and endocrinology of the menopause. Medicine. 2006;1(34):27-30
38
7. Burger HG, Dudley EC, Robertson DM, Dennerstein L. Hormonal changes in the menopause transition. Recent Progress in Hormone Research. 2002;57:257-75. doi: 10.1210/rp.57.1.257.
39
8. Kazemzadeh R, Nikjou R, Rostamnegad M, Norouzi H. Effect of lavender aromatherapy on menopause hot flushing: a crossover randomized clinical trial. Journal of the Chinese Medical Association. 2016;79(9):489-92. doi: 10.1016/j.jcma.2016.01.020.
40
9. Lindsay R. The menopause and osteoporosis. Obstetrics & Gynecology. 1996;87(2 Suppl):16S-19S. doi: 10.1016/0029-7844(95)00430-0.
41
10. Sarkar M, Wolf MG. Simple ovarian cysts in postmenopausal women: scope of conservative management. European Journal of Obstetrics & Gynecology and Reproductive Biology 2012;162(1):75-8. doi: 10.1016/j.ejogrb.2011.12.034.
42
11. Park J, Kim TH, Lee HH, Lee W, Chung SH. Ovarian rete cyst in a post-menopausal woman: a case report. The Journal of Korean Society of Menopause. 2012;18(1):67-69.https://doi.org/10.6118/jksm.2012.18.1.67
43
12. Darblade B, Pendaries C, Krust A, Dupont S, Fouque MJ, Rami J,et al. Estradiol alters nitric oxide production in the mouse aorta through the α-, but not β-, estrogen receptor. Circulation Research. 2002;90(4):413-9. doi: 10.1161/hh0402.105096.
44
13. Tsuda K, Kinoshita Y, Nishio I. Synergistic role of progesterone and nitric oxide in the regulation of membrane fluidity of erythrocytes in humans: an electron paramagnetic resonance investigation. American Journal of Hypertension. 2002;15(8):702-8. doi: 10.1016/s0895-7061(02)02965-5.
45
14. Tousoulis D, Kampoli AM, Tentolouris Nikolaos Papageorgiou C, Stefanadis C. The role of nitric oxide on endothelial function. Current Vascular Pharmacology. 2012;10(1):4-18. doi: 10.2174/157016112798829760.
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15. Yallampalli C, Byam-Smith M, Nelson SO, Garfield RE. Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus. Endocrinology. 1994134(4):1971-4 doi: 10.1210/endo.134.4.8137765.
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16. Gol A, Sofiabadi M, Abbasnejad M, Parvizi MR. The Regulatory Effect of Female Sex Steroid Hormones on Nitric Oxid Production. Journal of Rafsanjan University of Medical Sciences 2003;2(3):124-30.
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17. Gol A, Sofiabadi M, Abbasnejad M, Parvizi MR. The Regulatory Effect of Female Sex Steroid Hormones on Nitric Oxid Production. Journal of Rafsanjan University of Medical Sciences 2003;2(3):124-30.
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26. Salvemini D, Ischiropoulos H, Cuzzocrea S. Roles of nitric oxide and superoxide in inflammation. Methods in molecular biology 2003:225:291-303. doi: 10.1385/1-59259-374-7:291.
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27. Cella M, Farina MG, Dominguez Rubio AP, Di Girolamo G, Ribeiro ML, Franchi AM. Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour. British Journal of Pharmacology 2010;161(4):844-55. doi: 10.1111/j.1476-5381.2010.00911.x.
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64
ORIGINAL_ARTICLE
The effect of crocin on hippocampal lipid peroxidation and histopathology following intracerebroventricular injection of colchicine in the rat
Background and Objective: Colchicine is a neurotoxin substance. Its intraventricular injection causes oxidative stress, inflammation, destruction of cholinergic and glutaminergic neurons and consequently impairs memory and learning. Crocin is an effective ingredient in saffron that has antioxidant and anti-inflammatory potential with beneficial effects on memory and learning. This study investigated the effect of crocin on lipid peroxidation and histological changes of the hippocampus following intracerebroventricular injection of colchicine in the rat.
Materials and Methods: 40 male rats were randomly divided into 5 groups as follows: 1-Sham, 2- Sham + crocin at a dose of 50 mg/kg, 3- Colchicine, 4- Colchicine + crocin at a dose of 10 mg/kg, and 5- Colchicine + crocin at a dose of 50 mg/kg. Cognitive disorder was induced by injection of colchicine bilaterally into the brain ventricles through stereotaxic surgery. Crocin was daily administered 2 days before surgery till day 7 after the surgery. In the third week after the surgery, malondialdehyde (MDA) was evaluated in hippocampal homogenate. The number of neurons was also studied by Nissl staining in CA1 and CA3 regions.
Results: The results showed that crocin treatment at a dose of 50 mg/kg significantly reduced MDA. Histopathological assessment did not show significant changes regarding neuronal number.
Conclusion: The findings of this study indicate the dose-dependent effect of crocin in reduction of hippocampal MDA following intracerebroventricular injection of colchicine in the rat. However, it is not effective regarding number of hippocampal pyramidal neurons after colchicine challenge.
https://jbcp.shahed.ac.ir/article_3298_3edbd28c335828646994adc44ae53d13.pdf
2021-06-28
47
51
10.22070/jbcp.2020.4968.1124
Crocin
Colchicine
Malondialdehyde
Hippocampus
Mehrdad
Roghani
mehjour@yahoo.com
1
Neurophysiology Research Center, Shahed University, Tehran, Iran.
LEAD_AUTHOR
Ensie
Azadi-Ahmadabadi
azadi@gmail.com
2
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran
AUTHOR
Zahra
Kiasalari
kiasalari@shahed.ac.ir
3
Neurophysiology Research Center, Shahed University, Tehran, Iran.
AUTHOR
Farzane
Fereidoni
fereidoni@yahoo.com
4
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran.
AUTHOR
Shahrame
Jalalzade ogvar
jalalzade@gmail.com
5
Department of Physiology, School of Medicine, Shahed University, Tehran, Iran.
AUTHOR
Altinoz E, etal. Neuroprotection against CCl4 induced brain damage with crocin in Wistar rats. Biotech Histochem 2018; 93(8):623-631. doi: 10.1080/10520295.2018.1519725.
1
Awasthi H, Kaushal D, Siddiqui HH. Chronic inhibition of central angiotensin-converting enzyme ameliorates colchicine-induced memory impairment in mice. Scientia Pharmaceutia 2012; 80(3):647-62. doi: 10.3797/scipharm.1203-06.
2
Chalatsa I, Arvanitis DA, Koulakiotis NS, Giagini A, Skaltsounis AL, Papadopoulou-Daifoti Z, et al. The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models. Frontiers in Neuroscience 2019; 13:249. doi: 10.3389/fnins.2019.00249. eCollection 2019.
3
Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F. Oxidative stress and the amyloid beta peptide in Alzheimer's disease. Redox Biology 2018; 14:450-464. doi: 10.1016/j.redox.2017.10.014.
4
Farkhondeh T, Samarghandian S, Shaterzadeh Yazdi H, F S. The protective effects of crocin in the management of neurodegenerative diseases: a review. American Journal of Neurodegenerative Disease 2018; 7(1):1-10. eCollection 2018.
5
Fathimoghadam H, Farbod Y, Ghadiri A, Fatemi R. Moderating effects of crocin on some stress oxidative markers in rat brain following demyelination with ethidium bromide. Heliyon 2019; 5(2):e01213. doi: 10.1016/j.heliyon.2019.e01213.
6
Gella A, Durany N. Oxidative stress in Alzheimer disease. Cell Adhesion and Migration 2009; 3(1):88-93. doi: 10.4161/cam.3.1.7402.
7
Joy T, Rao MS, Madhyastha S. N-Acetyl cysteine supplement minimize Tau expression and neuronal loss in animal model of Alzheimer's disease. Brain Sciences 2018; 8(10):185. doi: 10.3390/brainsci8100185.
8
Leung YY, Yao Hui LL, Kraus VB. Colchicine--Update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum 2015; 45(3):341-50. doi: 10.1016/j.semarthrit.2015.06.013.
9
Mohammadi E, Mehri S, Badie Bostan H, Hosseinzadeh H. Protective effect of crocin against D-galactose-induced aging in mice. Avicenna Journal of Phytomedicine 2018; 8(1):14-23. PMID: 29387570
10
More SV, Kumar H, Cho DY, Yun YS, Choi DK. Toxin-induced experimental models of learning and memory impairment. International Journal of Molecular Sciences 2016; 17(9):1447. doi: 10.3390/ijms17091447.
11
Naghizadeh B, Mansouri M, Ghorbanzadeh B, Farbood Y, Sarkaki A. Protective effects of oral crocin against intracerebroventricular streptozotocin-induced spatial memory deficit and oxidative stress in rats. Phytomedicine 2013; 20(6):537-42. doi: 1016/j.phymed.2012.12.019.
12
Shibli R A, Daradkah NQ, Makhadmeh IM. Colchicine production from colchicum and the role of in vitro cultures: A Review. Jordan Journal of Agricultural Sciences 2010; 6(2):208-23.
13
Sil S, Ghosh R, Sanyal M, Guha D, Ghosh T. A comparison of neurodegeneration linked with neuroinflammation in different brain areas of rats after intracerebroventricular colchicine injection. Journal of Immunotoxicology 2016; 13(2):181-90. doi: 10.3109/1547691X.2015.1030804
14
Slobodnick A, Shah B, Pillinger MH, S K. Colchicine: old and new. American Journal of Medicine 2015; 128(5):461-70. doi: 10.1016/j.amjmed.2014.12.010.
15
Tamaddonfard S, Farshid AA, Asri-Rezaee S. Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats. Iranian Journal of Basic Medical Sciences 2013; 16(1):91-100. doi:10.22038/IJBMS.2013.253.
16
ORIGINAL_ARTICLE
Larvicidal activity of Zataria multiflora, Eucalyptus caesia Benth and Mentha piperita against Culex mosquito
Background and Objective: Mosquito is a vector of several life threatening diseases affecting humans. The use of synthetic insecticides in the vector control is not advisable due to concern about environmental sustainability, harmful effect on human health and increasing insecticide resistance. So, the objective of this study was to assess larvicidal activity of essential oils (EOs) of Zataria multiflora, Eucalyptus caesia Benth, and Mentha piperita against the Culex mosquito. Materials and Methods: The larvicidal activity of the essential oils were tested according to the WHO procedure. The larvae exposed to three-fold serial dilution of oils (2.5-400 ppm) using a dipping method for 24 h and then simultaneously each replicate was incubated in separate petri dishes at 27°C and 80-90% relative humidity. Mortality rate was recorded after an exposure of 24 h. LC50 and LC90 were calculated using Probit analysis and all data were analyzed using ANOVA and post hoc Tukey test. Results: In the comparative analysis of the essential oils, LC50 & LC90 of Z. multiflora, E. caesia Benth and M. piperita were5.09429 and26.9919, 3.66376 and 35.3173, and 8.3115 and 218.888 ppm, respectively. Also, as the concentration of essential oil increased, mortality rate of larvae increased too. Conclusion: This study concluded that the essential oils of Z. multiflora, E. caesia Benth and M. piperita have appropriate larvicidal activity against Culex, therefore, they can be used as good alternative to the Culex biological control.
https://jbcp.shahed.ac.ir/article_3295_eb9b3fd72177efaaf7b991b395ec0aa1.pdf
2021-06-28
52
57
10.22070/jbcp.2021.14347.1141
Culex
Eucalyptus caesia Benth
larvicidal activity
Mentha piperita
Zataria multiflora
Fatemeh
Hoseinpour
fhossainpour@yahoo.com
1
Department of Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
LEAD_AUTHOR
Yaser
Pirali Kheirabadi
khpirali@yahoo.com
2
Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
AUTHOR
Maedeh
Shahpasandi
shahpasandi.ma@gmail.com
3
Department of Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
AUTHOR
Abbott WS. A method of computing the effectiveness of an insecticide. Journal of Economic Entomology 1925; 18: 265-7. PMID: 3333059.
1
Africa: myths and reality. Malaria Journal 2011; 10:353. doi: 10.1186/1475-2875-10-353.
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Arun KD, Suresh Kumar J, Swamy PS. Larvicidal activity and leaf essential oil composition of three species of genus Atalantia from south India. International Journal of Mosquito Research 2015;2(3):25-29.
3
Brown AW. Insecticide resistance in mosquitoes: a pragmatic review. Journal of the American Mosquito Control Association 1986;2(2):123-140. PMID: 2906965
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Cetin H, Kurt Y, Isik K, Yanikoglu A. Larvicidal effect of Cedrus libani seed oils on mosquito Culex pipiens. Pharmaceutical Biology 2009;47(8):665–8. https://doi.org/10.1080/13880200902918360
5
Fatope MO, Ibrahim H, Takeda Y. Screening of higher plants reputed as pesticides using the Brine Shrimp Lethality Assay. International Journal of Pharmacognosy 2008;31(4): 250-254. https://doi.org/10.3109/13880209309082949.
6
Fazeli MR, Amin GR, Ahmadian Attari MM, Ashtiani H, Jamalifar H, Samadi N. Antimicrobial activities of Iranian sumac and avishan-e shirazi (Zataria multiflora) against some food-borne bacteria. Food Control 2007;18(6):646-649. https://doi.org/10.1016/j.foodcont.2006.03.002
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Fillinger U, Lindsay, SW. Larval source management for malaria control in
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Finney DJ. Probit Analysis. 3rd ed. London, UK: Cambridge University Press 1971.
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Gavanji S, Sayedipour SS, Larki B, Bakhtari, A. Antiviral activity of some plant oils against herpes simplex virus type 1 in Vero cell culture. Journal of Acute Medicine 2015;5(3):62–8. https://doi.org/10.1016/j.jacme.2015.07.001
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Herro E & Jacob SE. Mentha piperita (peppermint). Dermatitis 2010;21(6):327–9. PMID: 21144345.
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Hosseinzadeh H , Ramezani M, Salmani GA. Antinociceptive, anti-infl ammatory and acute toxicity eff ects of Zataria multifl ora Boiss extracts in mice and rats. Journal of Ethnopharmacology. 2000;73(3):379-385. https://doi.org/10.1016/S0378-8741(00)00238-5
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Howard AFV, Adongo EA, Vulule J, Githure J. Effects of a botanical larvicide derived from Azadirachta indica (the neem tree) on oviposition behaviour in Anopheles gambiae s.s. mosquitoes. Journal of Medicinal Plants Research 2011;5(10):1948-1954.
13
Khanikor B, Parida P, Yadav RNS, Bora D. Comparative mode of action of some terpene compounds against octopamine receptor and acetyl cholinesterase of mosquito and human system by the help of homology modeling and Docking studies. Journal of Applied Pharmaceutical Sciences 2013;3(2):6-12. doi: 10.7324/JAPS.2013.30202
14
Kishore N, Mishra BB, Tiwari VK, Tripathi V. Opportunity, challenge and scope of natural products in medicinal chemistry. Kerala: Research Signpost 2011; 335–365.
15
Kyarimpa CM, Bohmdorfer S, Wasswa J, Kiremire BT, Ndiege IO, Kabasa JD. Essential oil and composition of Tagetes minuta from Uganda. Larvicidal activity on Anopheles gambiae. Industrial Crops and Products 2014;62:400-404. https://doi.org/10.1016/j.indcrop.2014.09.006.
16
Mahendran G & Rahman LU. Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha piperita L.)- A review. Phytotherapy Research 2020; 34(9):2088-2139. doi: 10.1002/ptr.6664.
17
Medlock JM, Hansford KM, Schaffner F, Versteirt V, Hendrickx G, Zeller H and et al. A review of the invasive mosquitoes in Europe: ecology, public health risks, and control options. Vector Borne Zoonotic Diseases 2012; 12(6):435-47. doi: 10.1089/vbz.2011.0814. Epub 2012 Apr 20.
18
Mehrsorosh H, Gavanji S, Larki B, Mohammadi MD, Karbasiun A, Bakhtari A and et al. Essential oil composition and antimicrobial screening of some Iranian herbal plants on Pectobacterium carotovorum. Global NEST Journal 2014;16:240-50.
19
Nathan SS. The use of Eucalyptus tereticornis Sm. (Myrtaceae) oil (leaf extract) as a natural larvicidal agent against the malaria vector Anopheles stephensi Liston (Diptera: Culicidae) Bioresource Technology 2007; 98(9):1856-60. doi: 10.1016/j.biortech.2006.07.044.
20
Pavela R, Kaffkova K, Kumsta M. Chemical composition and larvicidal activity of essential oils from different Mentha L. and Pulegium species against Culex quinquefasciatus Say (Diptera: Culicidae). Plant Protection Science 2014; 50(1): 36-41. doi:10.17221/48/2013-PPS.
21
Pavela R, Vrchotova N, Triska J. Larvicidal activity of extracts from Ammi visnaga Linn. (Apiaceae) seeds against Culex quinquefasciatus Say. (Diptera: Culicidae). Experimental Parasitology 2016; 165:51-7. doi: 10.1016/j.exppara.2016.03.016.
22
Roberts JR, Karr CJ. Pesticide exposure in Children. Pediatrics 2012; 130(6):e1765-88. doi: 10.1542/peds.2012-2758.
23
Sajed H, Sahebkar AH, Iranshahi M. Zataria multiflora Boiss. (Shirazi thyme)—An ancient condiment with modern pharmaceutical uses. Journal of Ethnopharmacology. 2013; 145(3):686-98. doi: 10.1016/j.jep.2012.12.018.
24
Schaffner F, Medlock JM, Van Bortel W. Public health significance of invasive mosquitoes in Europe. Clinical Microbiology and Infection 2013;19(8):685–92. https://doi.org/10.1111/1469-0691.12189
25
Schnitzler P, Schon K, Reichling J. Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Die Pharmazie. 2001;56(4):343-347. PMID: 11338678
26
Senthil-Nathan S. A review of biopesticides and their mode of action against insect pests. Edition: 2015 Publisher: Springer ISBN: 978-81-322-2056-5
27
Sharififar F,Derakhshanfar A, Dehghan-Nudeh GR, Abbasi N, Abbasi R, Rezaei Gharaei R and et al. In vivo antioxidant activity of Zataria multiflora Boiss essential oil. Pakistan Journal of Pharmaceutical Sciences. 2011;24(2):221-225. PMID: 21454174
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Tolle MA. Mosquito-borne diseases. Currrent Problems in Pediatric and Adolescent Health Care 2009;39(4):97-140.
29
Tsai ML, Wu CT, Lin TF, Lin WC, Huang YC, Yang CH. Chemical composition and biological properties of essential oils of two mint species. Tropical Journal of Pharmaceutical Research 2013;12(4):577-582.
30
Vatandoost H, Vaziri VM. Larvicidal activity of neem tree extract (Neemarin) against mosquito larvae in the Islamic Republic of Iran. Eastern Mediterranean Health Journal 2004; 10(4-5):573-81. PMID: 16335649.
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33
ORIGINAL_ARTICLE
Effect of simultaneous injection of l-arginine in dorsal hippocampus and laterodorsal periaqueductal gray matter on morphine-induced analgesia in rat’s formalin test
Background and Objective: Injection of l-arginine, a precursor of nitric oxide, in the rat’s hippocampus or periaqueductal gray matter reduces the analgesic effect of morphine on formalin-induced pain, but the effect of simultaneous injection of the substance in both areas have not been shown as our purpose of this research. Materials and Methods: Wistar rats were used as control, morphine, and l-arginine groups. The rats were simultaneously cannulated in two areas of the dorsal hippocampus and laterodorsal PAG. One week later, the control animals received 50 μl of 2.5% formalin in the paw of the left foot under restrainer. The morphine group 10 min before formalin received the opioid (6 mg/kg, intraperitoneally). Other groups took l-arginine (0.25-2 µg/rat) in only one area (d hippocampus or ld PAG), prior to morphine administration. The effective dose of l-arginine (0.5 µg/rat) simultaneously was injected in both areas. The findings were analyzed by analysis of variance (ANOVA) under α=0.05. Results: Morphine induced analgesic response. Injection of NO precursor both separately and simultaneously in the two nuclei reduced morphine-induced analgesia. Conclusion: Increasing levels of NO due to exclusive or concurrent injection of l-arginine in the areas likely antagonize the morphine response.
https://jbcp.shahed.ac.ir/article_3297_395417ad3b633c4c9ad45e866f69e479.pdf
2021-06-28
52
57
10.22070/jbcp.2021.14570.1144
L-arginine
PAG
Hippocampus
Formalin test
Mahboobeh
Hashemi
mahboobm80@gmail.com
1
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
AUTHOR
Manizheh
Karami
karamip14@gmail.com
2
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
LEAD_AUTHOR
Mohammadreza
Zarrindast
zarinmr@ams.ac.ir
3
Department of Pharmacology, School of Pharmacy, Tehran University of Medical Sciences,Tehran, Iran
AUTHOR
Tenopoulou M, Doulias PT. Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism. F1000 Research 2020; 9:F1000 Faculty Rev-1190. doi: 10.12688/f1000research.19998.1. eCollection 2020.
1
Ghimire K, Altmann HM, Straub AC, Isenberg JS. Nitric oxide: what's new to NO?. American Journal of Physiology 2017; 312(3):C254-C262. doi: 10.1152/ajpcell.00315.2016.
2
Zhang N, Beuve A, Townes-Anderson E. The nitric oxide-cGMP signaling pathway differentially regulates presynaptic structural plasticity in cone and rod cells. The Journal of Neuroscience 2005 ; 25(10):2761-70. doi: 10.1523/JNEUROSCI.3195-04.2005.
3
Cury Y, Picolo G, Gutierrez V. Pain and analgesia: The dual effect of nitric oxide in the nociceptive system. Nitric Oxide 2011; 25(3):243-54. doi: 10.1016/j.niox.2011.06.004.
4
LIU M-G, Chen J. Roles of the hippocampal formation in pain information processing. Neuroscience Bulletin 2009; 25(5):237-66. doi: 10.1007/s12264-009-0905-4.
5
Toda N, Kishioka S, Hatano Y, Toda H. Modulation of opioid actions by nitric oxide signaling. Anesthesiology 2009; 110(1):166-81. doi: 10.1097/ALN.0b013e31819146a9.
6
Nazeri M, Razavinasab M, Abareghi F, Shabani M. Role of nitric oxide in altered nociception and memory following chronic stress. Physiology Behavior 2014; 129:214-20. doi: 10.1016/j.physbeh.2014.02.054.
7
TadeuMiguela T, LuizNunes-de-Souza R. Defensive-like behaviors and antinociception induced by NMDA injection into the periaqueductal gray of mice depend on nitric oxide synthesis. Brain Research 2006; 1076(1):42-8. doi: 10.1016/j.brainres.2005.12.095. Epub 2006 Feb 13.
8
Emmanouil DE. Nitrous oxide-antinociception is mediated by opioid receptors and nitric oxide in the periaqueductal gray region of the midbrain. European Neuropsychopharmacology 2008; 18(3):194-9. doi: 10.1016/j.euroneuro.2007.06.008.
9
Benarroch EE. Periaqueductal gray; An interface for behavioral control. Neurology 2012; 78(3):210-7. doi: 10.1212/WNL.0b013e31823fcdee.
10
Tyrtyshnaia A, Manzhulo I. Neuropathic Pain Causes Memory Deficits and Dendrite Tree Morphology Changes in Mouse Hippocampus. Journal of Pain Researcg 2020; 13:345-354. doi: 10.2147/JPR.S238458.
11
Hafeshjani ZK, Karami M, Biglarnia M. Nitric oxide in the hippocampal cortical area interacts with naloxone in inducing pain. Indian Journal of Pharmacology 2012; 44(4):443-7. doi: 10.4103/0253-7613.99299.
12
Hashemi M, Karami M, Zarrindast MR, Sahebgharani M. Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception. Brain Research 2010; 1313:79-88. doi: 10.1016/j.brainres.2009.11.020.
13
Huang J, Gadotti VM, Chen L, Souza IA, Huang S, Wang D, Ramakrishnan C, Deisseroth K, Zhang Z, Zamponi GW. A neuronal circuit for activating descending modulation of neuropathic pain. Nature Neuroscience 2019; 22(10):1659-1668. doi: 10.1038/s41593-019-0481-5.
14
Lin J, Zhang X, Li C, Zhang Y, Lu H, Chen J, Li Z, Yang X, Wu Z. Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response. Journal of Ethnopharmacology 2020; 254:112727. doi: 10.1016/j.jep.2020.112727.
15
Ally A, Powell I, Ally MM, Chaitoff K, Nauli SM. Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states. Nitric Oxide 2020; 102:52-73. doi: 10.1016/j.niox.2020.06.004.
16
Thompson JM, Neugebauer V. Cortico-limbic pain mechanisms. Neuroscience Letter 2019; 702:15-23. doi: 10.1016/j.neulet.2018.11.037.
17