ORIGINAL_ARTICLE
The effect of exercise during pregnancy on health-related quality of life and depression
Background and Objective: Exercise has different physical and psychological benefits and can help ameliorate women’s physical and psychological changes during pregnancy. This study aimed to investigate the effects of exercise during pregnancy on women’s weight gain, health-related quality of life (HR-QOL), and depression, and neonates’ birth weight and type of childbirth.
Materials and Methods: One hundred women who referred to Mostafa Khomeini Hospital (Tehran) from December 2016 to November 2017 for prenatal care were included into this study and randomized into two groups: the case group (n=50) with women whom exercised for 60 minutes 3 times a week for 12 weeks and the control group (n=50) with no exercise. At baseline and after 12 weeks, both groups completed SF-36 and Edinburg questionnaires for assessing their HR-QOL and depression, respectively. The type of childbirth, neonate’s birth weight, and women’s weight after childbirth were recorded.
Results: The case group had a significantly lower mean ±SD weight gain after 12 weeks as compared with the control group (4.9±1.50 kg vs 6.50±2.47 kg) (P=0.007), and a lower rate of cesarean section (P=0.001). The mean ±SD of neonates’ birth weight was not different between the two groups (P=0.89). The total scores of SF-36, physical and social dimensions, and general health improved in the case group, while significantly decreased in the control group (P<0.05).
Conclusion: Exercise during pregnancy can reduce cesarean section rate and results in less weight gain after pregnancy. It can also improve patients’ HR-QOL and decrease depression. Therefore, it is suggested to be included in the prenatal care protocol.
https://jbcp.shahed.ac.ir/article_3454_1dd967b866e7dfb0f0c7bad7a42fd8c0.pdf
2021-11-01
1
10
10.22070/jbcp.2021.15276.1153
Exercise
Pregnancy
Quality of Life
Depression
Ahia
Garshasbi
garshasbi@shahed.ac.ir
1
Department of Gynecology and Obstetrics, Faculty of Medicine, Shahed University, Tehran, Iran
LEAD_AUTHOR
Maryam
Adinehvand
mary_iranian2002@yahoo.com
2
Master of Midwifery, Department of Obstetrics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Anoshirvan
Kazemnejad
kazem_an@modares.ac.ir
3
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
AUTHOR
Neiger R. Long-term effects of pregnancy complications on maternal health: a review. Journal of Clinical Medicine 2017; 6(8):76. https://doi.org/10.3390/jcm6080076
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2
Johnson J, Clifton RG, Roberts JM, et al. Pregnancy outcomes with weight gain above or below the 2009 Institute of Medicine guidelines. Obstetrics and Gynecology 2013;121(5):969-975. https://dx.doi.org/10.1097%2FAOG.0b013e31828aea03.
3
Goldstein RF, Abell SK, Ranasinha S, et al. Association of Gestational Weight Gain With Maternal and Infant Outcomes: A Systematic Review and Meta-analysis. Journal of the American Medical Association 2017;317(21):2207-2225. https://doi.org/10.1001/jama.2017.3635
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19
Bergink V, Kooistra L, Lambregtse-van den Berg MP, et al. Validation of the Edinburgh Depression Scale during pregnancy. Journal of Psychosomatic Research 2011;70(4):385-389. https://doi.org/10.1016/j.jpsychores.2010.07.008
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21
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22
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23
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24
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25
Bisson M, Alméras N, Dufresne SS, et al. A 12-Week Exercise Program for Pregnant Women with Obesity to Improve Physical Activity Levels: An Open Randomised Preliminary Study. PLoS One 2015;10(9):e0137742. https://doi.org/10.1371/journal.pone.0137742
26
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27
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31
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37
ORIGINAL_ARTICLE
The extraordinary efficacy of platelet rich fibrin membrane on fungal infections of nails in a human model
Background: Fungal infections of nail can occur in people with brittle and dry skin. This condition can lead to nail damage and infection that spread beyond your feet if you have a suppressed immune system due to medication, diabetes or other conditions. If the immune system is suppressed due to medication, diabetes or other conditions, they expand. Some patients do not respond appropriately to common treatments. The use of platelet rich fibrin membrane (PRF M) has been suggested as an alternative method for fungal infection of nail treatment due to their potential to release many kinds of growth factors and antifungal efficacy.Materials and Methods: The PRF M sample was obtained from the patient with fungal nail infection. PRF M was harvested from peripheral blood by centrifuging immediately. Moreover, PRF M was expanded over the damaged area in flat form five times for three days. Pre-treatment and post-treatment were then analyzed by observation of fungal infection.Results: Visual observation showed the positive effect of this technique on the patient's recovery. Hence, it can be deduced that autologous PRF M is a promising safe therapy for drug-resistant fungal infections.Conclusion: The present clinical case report demonstrated that PRF M may be able to remove fungal infections in human.
https://jbcp.shahed.ac.ir/article_3455_1c3ccee42343e75f6d8c6930d24829a5.pdf
2021-12-30
11
14
10.22070/jbcp.2021.15252.1152
Platelet rich fibrin membranes
Fungal infection of nail
antifungal efficacy
regeneration
Mahdieh
Ghiasi
mahdieh.ghiasi@yahoo.com
1
Iranian Tissue Bank & Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Mohammad
Bigdello
mahdieh.ghiasi1360@gmail.com
2
Department of Surgery, Qom University of Medical Sciences, Qom, Iran
AUTHOR
Amirali
Hamidieh
3
Iranian Tissue Bank & Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Foley K, Gupta AK, Versteeg S, Mays R, Villanueva E, John D. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database of Systematic Reviews 2020; 16:1(1).
1
Giudice A, Antonelli A, Muraca D, Fortunato L. Usefulness of advanced-platelet rich fibrin (A-PRF) and injectable-platelet rich fibrin (i-PRF) in the management of a massive medication-related osteonecrosis of the jaw (MRONJ): A 5-years follow-up case report. Indian Journal of Dental Research 2020; 31(5):813-818.
2
Ghiasi M, Farzaneh S, Bigdelo M. Assessment of human cartilage regeneration in a patient with knee osteoarthritis using autologous adipose-tissue-derived stem cells and Platelet-rich plasma: a case study Journal of Surgery and Trauma 2020; 8(2):73-78. Journal of Surgery and Trauma 2020; 8(2):73-78.
3
Naik B, Karunakar P, Jayadev M, Marshal VR. Role of platelet rich fibrin in wound healing: A critical review. Journal of Conservative Dentistry 2013; 16:284–93.
4
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surgery, Oral Medicine, Oral Pathology Oral Radiology 2006; 101:e56–60.
5
Lucarelli E, Beretta R, Dozza B, Tazzari PL, O'Connel SM, Ricci F, et al. A recently developed bifacial platelet-rich fibrin matrix. European Cells & Materials Journal 2010; 20:13–23.
6
Inchingolo F, Cantore S, Dipalma G, Georgakopoulos I, Almasri M, Gheno E, et al. Platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: a clinical and histopathological evaluation. Journal of Biological Regulators & Homeostatic Agents 2017; 31(3):811-816.
7
Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. Journal of Indian Society of Periodontology 2017; 21:97–101.
8
Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. Journal of Interferon & Cytokine Research 2002; 22:913–22.
9
Tang YQ, Yeaman MR, Selsted ME. Antimicrobial peptides from human platelets. Infection and Immunity 2002; 70:6524–33.
10
Ramadan A. Ali, Leah M. Wuescher, and Randall G. Platelets: essential components of the immune system. Current Trends in Immunology 2015; 16: 65–78.
11
Yeaman MR, Tang YQ, Shen AJ, Bayer AS, Selsted ME. Purification and in vitro activities of rabbit platelet microbicidal proteins. Infection and Immunity 1997; 65:1023–31.
12
Toffler M, Toscano N, Holtzclaw D, Corso MD, Ehrenfest DD. Introducing Choukroun's platelet rich fibrin (PRF) to the reconstructive surgery milieu. Journal of Implant & Advanced Clinical Dentistry 2009; 1:21–30.
13
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surgery, Oral Medicine, Oral Pathology Oral Radiology 2006; 101:e45–50.
14
Bielecki T, Dohan Ehrenfest DM, Everts PA, Wiczkowski A. The role of leukocytes from L-PRP/L-PRF in wound healing and immune defense: New perspectives. Current Pharmaceutical Biotechnology 2012; 13:1153–62.
15
ORIGINAL_ARTICLE
Effect of apigenin on endothelium-dependent relaxation of aorta in streptozotocin-induced diabetic rats
Objective: The current study aimed at evaluating the effect of flavonoid apigenin on contractile response and relaxation of aorta in streptozotocin (STZ)-induced diabetic rats.Materials and Methods: Thirty-two rats were randomly divided into four groups of control, apigenin, diabetic (DM), and DM + apigenin. DM was induced in rats using intraperitoneal (i.p.) injection of STZ at 60 mg/kg. The two treatment groups received apigenin at a dose of 10 mg/kg i.p. every other day for four weeks. At the end of the study, the contractile responses of aorta to potassium chloride (KCL), phenylephrine (PE), and the relaxation response of the aorta to acetylcholine (ACh) were measured.Results: Treatment with apigenin significantly reduced plasma glucose in diabetic rats in the 2nd and 4th weeks as compared to those of the DM group (P = 0.01). The DM+apigenin group had less contractile response as compared to that of the DM group, although the difference was not statistically significant (P >0.05). Treatment of diabetic rats with apigenin could significantly reduce the maximum contractile response as compared to that of the DM group (P = 0.05). The contractile response to ACh was significantly higher in the DM + apigenin group as compared to that of the DM group (P = 0.05).Conclusion: The results of the current study indicated the hypoglycemic effects of apigenin in diabetic rats. In addition, it was observed that the administration of apigenin to diabetic and healthy rats could reduce contractile response of aorta to PE and increase the relaxation response to ACh.
https://jbcp.shahed.ac.ir/article_3456_e8a4635d0bbcf8b98650a5a275738325.pdf
2021-12-30
15
21
10.22070/jbcp.2021.15168.1150
Apigenin
Diabetes mellitus
Aorta
Streptozotocin
Endothelium
Mohamadreza
Rajabi
rajabim2000@yahoo.com
1
Department of Cardiology, Faculty of Medicine, Shahed University, Tehran, Iran.
AUTHOR
Mehrdad
Roghani
mehjour@yahoo.com
2
Neurophysiology Research Center, Shahed University, Tehran, Iran
AUTHOR
Iman
Ansari
dransarieman@yahoo.com
3
Medical Students Research Committee, Shahed University, Tehran, Iran
LEAD_AUTHOR
Elahe
Rashidi
110soushiant@gmail.com
4
Faculty of Medicine, Shahed University, Tehran, Iran
AUTHOR
Elnaz
Babakhani
elnaaz.babakhani@gmail.com
5
Medical Students Scientific Association, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Saba
Ansari
biol.sabaansari@gmail.com
6
Department of Cellular and Molecular Biology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Research and Clinical Practice 2018;138:271-281. doi: 10.1016/j.diabres.2018.02.023.
1
Vrsalovic M, Vucur K, Vrsalovic Presecki A, Fabijanic D, Milosevic M. Impact of diabetes on mortality in peripheral artery disease: a meta-analysis. Clinical Cardiology 2017;40(5):287-291. doi: 10.1002/clc.22657.
2
Ghosian Moghadam MH, Ansari I, Roghani M, Ghanem A, Mehdizade N. The Effect of Oral Administration of Hypericum Perforatum on Serum Glucose and Lipids, Hepatic Enzymes and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats. Galen Medical Journal 2017; 6(4):319-329. doi: 10.22086/gmj.v6i4.889
3
Fallahi F, Roghani M, Ansari I. The effect of hydroalcoholic extract of Cydonia oblonga Miller leaf on doxorubicin-induced cardiac injury in rat. Journal of Basic and Clinical Pathophysiology 2018;6(2):7-12. doi: 10.22070/jbcp.2018.3215.1096
4
Malik S, Suchal K, Khan SI, Bhatia J, Kishore K, Dinda AK, Arya DS. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. American Journal of Physiology-Renal Physiology 2017;313(2):F414-F422. doi: 10.1152/ajprenal.00393.2016.
5
Ren B, Qin W, Wu F, Wang S, Pan C, Wang L, et al. Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. European Journal of Pharmacology 2016 ;773:13-23. doi: 10.1016/j.ejphar.2016.01.002.
6
Qin W, Ren B, Wang S, Liang S, He B, Shi X, et al. Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. Vascular Pharmacology 2016;85:39-49. doi: 10.1016/j.vph.2016.07.006.
7
Mahajan UB, Chandrayan G, Patil CR, Arya DS, Suchal K, Agrawal YO, et al. The Protective Effect of Apigenin on Myocardial Injury in Diabetic Rats mediating Activation of the PPAR-γ Pathway. International Journal of Molecular 2017;18(4). pii: E756. doi: 10.3390/ijms18040756.
8
Liu HJ, Fan YL, Liao HH, Liu Y, Chen S, Ma ZG, et al. Apigenin alleviates STZ-induced diabetic cardiomyopathy. Molecular and Cellular Biochemistry 2017;428(1-2):9-21. doi: 10.1007/s11010-016-2913-9.
9
Jin BH, Qian LB, Chen S, Li J, Wang HP, Bruce IC, et al. Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. European Journal of Pharmacology 2009 ;616(1-3):200-5. doi: 10.1016/j.ejphar.2009.06.020.
10
Sui H, Zhi Y, Liu H, Gao P, Xu H, Yan W. Endothelium-dependent vasorelaxation effects induced by apigenin on the thoracic aorta of rats and its possible mechanism. Wei Sheng Yan Jiu 2011;40(4):416-9, 422.
11
Fallahi F, Roghani M, Moghadami S. Citrus flavonoid naringenin improves aortic reactivity in streptozotocin-diabetic rats. Indian Journal of Pharmacology 2012;44(3):382-6. doi: 10.4103/0253-7613.96350
12
Mahdavi MR, Roghani M, Baluchnejadmojarad T. Mechanisms responsible for the vascular effect of aqueous Trigonella foenum-graecum leaf extract in diabetic rats. Indian Journal of Pharmacology 2008;40(2):59-63. doi: 10.4103/0253-7613.41039
13
Qian LB, Fu JY, Cai X, Xia ML. Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas. Indian Journal of Pharmacology 2012;44(5):588-92. doi: 10.4103/0253-7613.100382.
14
Pennathur S, Heinecke JW. Oxidative stress and endothelial dysfunction in vascular disease. Current Diabetes Reports 2007;7(4):257-64.
15
Suh KS, Oh S, Woo JT, Kim SW, Kim JW, Kim YS, et al. Apigenin attenuates 2-deoxy-D-ribose-induced oxidative cell damage in HIT-T15 pancreatic β-cells. Biological and Pharmaceutical Bulletin 2012;35(1):121-6.
16
Wang N, Yi WJ, Tan L, Zhang JH, Xu J, Chen Y, et al. Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. In Vitro Cellular & Developmental Biology 2017;53(6):554-563. doi: 10.1007/s11626-017-0135-4.
17
Yamagata K, Miyashita A, Matsufuji H, Chino M. Dietary flavonoid apigenin inhibits high glucose and tumor necrosis factor alpha-induced adhesion molecule expression in human endothelial cells. Journal of Nutritional Biochemistry 2010;21(2):116-24. doi: 10.1016/j.jnutbio.2008.11.003.
18
ORIGINAL_ARTICLE
Evaluation of the anti-depressant effect of metformin in ovariectomized mice: possible involvement of nitrergic and serotoninergic systems
Background and Objective: Depressive disorders are the most prevalent form of the mental disorders in postmenopausal and there is information for beneficial effects of the metformin (MET) in depression. However, there is no report on anti-depressant effect of the MET during postmenopausal period. Thus, the aim of this study was to determine anti-depressant effect of the MET in ovariectomized (OVX) mice and possible involvement of nitrergic and serotoninergic systems.Materials and Methods: Two hundred and fifty female NMRI mice were randomly allocated into 5 experimental groups (each with 5 groups [A-E], n=50). In experiment 1, mice allocated as (A) control, (B) OVX injected with saline, (C) OVX injected with MET (100 mg/kg), (D) OVX mice injected with MET (200 mg/kg), (E) OVX injected with MET (400 mg/kg) at 24, 6 and 1 h prior the test. In experiment 2, experimental grouping was (A) control, (B) OVX injected with saline, (C) OVX mice injected with MET (400 mg/kg), (D) OVX mice injected with L-NAME (10 mg/kg), (E) OVX mice injected with MET (400 mg/kg) + L-NAME (10 mg/kg). Experiments 3-5 were similar to experiment 2, except OVX mice injected with L-arginine (50 mg/kg), cyproheptadine (4 mg/kg) and fluoxetine (5 mg/kg) instead of L-arginine. Following injections forced swimming test (FST), tail suspension test (TST) and open field test (OFT) were done. At the end of the study, serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS) were determined.Results: According to the results, MET (200 and 400 mg/kg) decreased immobility time in TST and FST (P<0.05). Co-injection of the MET+L-NAME decreased immobility time in TST and FST (P<0.05). Co-injection of MET+L-arginine significantly diminished antidepressant activity of the MET (P<0.05). MET + cyproheptadine decreased antidepressant activity of the MET (P<0.05). MET + fluoxetine significantly amplified antidepressant activity of the MET (P<0.05). MET (200 and 400mg/kg) improved serum MDA, SOD and GPx levels (P<0.05).Conclusion: It seems that antidepressant activity of the MET is mediated by nitrergic and serotoninergic system in OVX mice.
https://jbcp.shahed.ac.ir/article_3457_5cdeec9ac5bcab528470dda86ec25ee9.pdf
2021-12-30
22
31
10.22070/jbcp.2021.15105.1149
Depression
Ovariectomy
Metformin
Nitric oxide
Serotonin
antioxidant
Estradiol deficiency
Pouya
Ahmad Arangeh
ahmadi@yahoo.com
1
Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Ahmad
Asghari
drahmadasghari@gmail.com
2
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Shahin
Hassanpour
hassanpour.shahin@gmail.com
3
Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
LEAD_AUTHOR
Alireza
Jahandideh
jahandided@yahoo.com
4
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Shu XY, Hou DB, Li F. Study on the content of alkaloids and polysaccharide in different varieties of aconitum carmichaeli. China Pharmacy 2010; 21:2916–2918.
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Anaraki DK, Sianati S, Sadeghi M, Ghasemi M, Javadi P, Mehr SE, et al. Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice. European Journal of Pharmacology 2008;586(1-3):189-96.
16
Sadeghi M, Sianati S, Anaraki DK, Ghasemi M, Paydar MJ, Sharif B, et al. Study of morphine-induced dependence in gonadectomized male and female mice. Pharmacology Biochemistry and Behavior 2009;91(4):604-9.
17
Mirbaha H, Tabaeizadeh M, Shaterian-Mohammadi H, Tahsili-Fahadan P, Dehpour AR. Estrogen pretreatment modulates morphine-induced conditioned place preference in ovariectomized mice. Pharmacology Biochemistry and Behavior 2009; 92, 399–403.
18
Castagné V, Moser P, Roux S, Porsolt RD. Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Current Protocols in Neuroscience 2011; https://doi.org/10.1002/04711 42301 .ns081 0as55 PMID:21462162
19
Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neuroscience & Biobehavioral Reviews 2005; 29:571-625.
20
Haj-Mirzaian A, Ostadhadi S, Kordjazy N, Dehpour AR, Mehr SE. Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test. European Journal of Pharmacology 2014;735:26-31.
21
Jang D, Elfenbein HA. Menstrual cycle effects on mental health outcomes: a meta-analysis. Archives of Suicide Research 2018: 20: 1–21.
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Freeman EW. Associations of depression with the transition to menopause. Menopause 2010; 17:823–7.
23
Wang P, Liu C, Liu L, Zhang X, Ren B, Li B. The Antidepressant-like Effects of Estrogen-mediated Ghrelin. Current Neuropharmacology 2015; 13:524–35.
24
Liu Y, Huang C, Ceng C, Zhan H, Zheng D, Han W. Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia. Lipids in Health and Disease 2014, 13:115.
25
Heydarpour P, Salehi-Sadaghiani M, Javadi-Paydar M, Rahimian R, Fakhfouri G, Khosravi M, et al. Estradiol reduces depressive-like behavior through inhibiting nitric oxide/cyclic GMP pathway in ovariectomized mice. Hormones and Behavior 2013; 63(2):361-9
26
Kulkarni SK, Dhir A. On the mechanism of antidepressant-like action of berberine chloride. European Journal of Pharmacology 2008; 589(1-3): 163-172.
27
Ostadhadi S, Jahanabadi S, Javadi Sh, Saadaei H, Zolfaghari S, Dehpour AR. The Involvement of Nitric Oxide in Antidepressant-Like Effect of Metformin after Bile-Duct Ligation in NMRI Mice. Caspian Journal of Neurological Sciences 2015; 1(3):1-10.
28
Guo M, Mi J, Jiang QM, Xu JM, Tang YY, Tian G, et al. Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus. Clinical and Experimental Pharmacology and Physiology 2014; 41(9): 650-656.
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Taleb S, Moghaddas P, Balaei MR, Taleb S, Rahimpour S, Abbasi A, et al. Metformin Improves Skin Flap Survival Through Nitric Oxide System. Journal of Surgical Research 2014;192(2):686-91.
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He H, Zhao Z, Chen J, Ni Y, Zhong J, Yan Z, et al. Metformin-based treatment for obesity-related hypertension: a randomized, double-blind, placebo-controlled trial. Journal of Hypertension 2012; 30:1430–1439.
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Liu KC, Li JY, Tan HH, Du CX, Xie W, Zhang YM, et al. Serotonin6 receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. Neuropharmacology 2015; 95:290-8.
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Poggini S, Golia MT, Alboni S, Milior G, Sciarria LP, Viglione A, et al. Combined fluoxetine and metformin treatment potentiates antidepressant efficacy increasing IGF2 expression in the dorsal hippocampus. Neural Plasticity 2019. https://doi.org/10.1155/2019/4651031
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Zemdegs J, Martin H, Pintana H, Bullich S, Manta S, Marqués MA, et al. Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids. Journal of Neuroscience 2019;39(30):5935-48.
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Khedr SA, Elmelgy AA, El-Kharashi OA, Abd-Alkhalek HA, Louka ML, Sallam HA, et al. Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression. Naunyn-Schmiedeberg's Archives of Pharmacology 2018;391(4):407-22.
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Antunes MS, Goes AT, Boeira SP, Prigol M, Jesse CR. Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice. Nutr 2014; 104:19–26.
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Woo YS, Lim HK, Wang SM, Bahk WM. Clinical evidence of antidepressant effects of insulin and anti-hyperglycemic agents and implications for the pathophysiology of depression—A literature review. International Journal of Molecular 2020;21(18):6969.
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Morris G, Berk M, Galecki P, Walder K, Maes M. The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases. Molecular Neurobiology 2016;53(2):1195-219.
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Papachristou S, Papanas N. Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?. Diabetes Therapy 2021; 12:965–968.
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46
ORIGINAL_ARTICLE
Anti-depressant effect of Artemisia dracunculus extract is mediated via GABAergic and serotoninergic systems in ovariectomized mice
Background and Objective: Depression is known as the most prevalent mental disorder and there is growing interest to use medical plants with lower side effects. So, the aim of current study was to determine anti-depressant effect of Artemisia dracunculus extract (ADE) in ovariectomized (OVX) mice and its possible interaction with opioidergic, GABAergic and serotoninergic systems.Materials and Methods: In experiment 1, mice were kept as control and sham groups, OVX, OVX+ ADE (12.5 mg/kg), OVX+ ADE (25 mg/kg) and OVX+ADE (50 mg/kg). In experiment 2, mice kept as control and sham, OVX, OVX+ ADE (50 mg/kg), OVX+naloxone (2 mg/kg) and OVX+injection of ADE and naloxone. Experiments 3-5 were similar to experiment 2, except injections of the flumazenil (5 mg/kg), fluoxetine (5 mg/kg) and cyproheptadine (4 mg/kg). Then, forced swimming test (FST), tail suspension test (TST) and open field test (OFT) tests were done. Also, serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS) levels were determined.Results: According to the findings, OVX increased immobility time compared to control group (P<0.05). ADE (50 mg/kg) decreased depression induced immobility time compared to OVX group (P<0.05). Injection of ADE+flumazenil decreased depression induced immobility time in TST and FST and increased number of crossing in OFT (P<0.05). Injection of ADE+fluoxetine decreased depression induced immobility time (P<0.05). ADE (25 and 50 mg/kg) reduced the MDA while elevated SOD and GPx levels in OVX mice (P<0.05).Conclusion: It seems that antidepressant activity of Artemisia dracunculus is mediated via GABAergic and serotoninergic systems in OVX mice.
https://jbcp.shahed.ac.ir/article_3458_dd7e0de317bcd1a2069ad02c85ac791d.pdf
2021-12-30
32
41
10.22070/jbcp.2021.15060.1148
Anti-depressant
Ovariectomy
Artemisia dracunculus
GABAergic
Serotoninergic
Asal
Ilkhanizadeh
asalilkhanizadeh@gmail.com
1
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Ahmad
Asghari
dr.ahmad.asghari@gmail.com
2
Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
LEAD_AUTHOR
Shahin
Hassanpour
hassanpour.shahin@gmail.com
3
Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Shahabeddin
Safi
shahab@yahoo.com
4
Department of Pathobiology, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Saravi SSS, Arefidoust A, Yaftian R, Saravi SSS, Dehpour AR. 17 alpha-ethinyl estradiol attenuates depressive-like behavior through GABA(A) receptor activation/nitrergic pathway blockade in ovariectomized mice. Psychopharmacology 2016; 233: 1467–1485
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Albert KM, Newhouse PA. Estrogen, stress, and depression: cognitive and biological interactions. Annual Review of Clinical Psychology 2019; 15:399-423
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Newhouse P, Albert K. Estrogen, stress, and depression: a neurocognitive model. JAMA Psychiatry 2015; 72(7):727–29
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Heydarpour P, Salehi-Sadaghiani M, Javadi-Paydar M, Rahimian R, Fakhfouri G, Khosravi M, et al. Estradiol reduces depressive-like behavior through inhibiting nitric oxide/cyclic GMP pathway in ovariectomized mice. Hormones and Behavior 2013; 63(2):361-9.
10
Haramipour P, Asghari A, Hassanpour S, Jahandideh A. Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice. Archives of Razi Institute. 2021 Jan 3.
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14
Kalbasi Anaraki D, Sianati S, Sadeghi M, Ghasemi M, Paydar MJ, Ejtemaei Mehr S, Dehpour AR (2008) Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice. European Journal of Pharmacology 586: 189-196.
15
Sadeghi M, Sianati S, Anaraki DK, Ghasemi M, Paydar MJ, Sharif B, Mehr SE, Dehpour AR. Study of morphine-induced dependence in gonadectomized male and female mice. Pharmacology Biochemistry and Behavior 2009; 91: 604–609.
16
Castagné V, Moser P, Roux S, Porsolt RD. Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Current Protocols in Neuroscience 2011; https://doi.org/10.1002/04711 42301 .ns081 0as55 PMID:21462162.
17
Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neuroscience & Biobehavioral Reviews 2005; 29(4–5):571–625.
18
Donato F, de Gomes MG, Goes AT, Filho CB, Del Fabbro L, Antunes MS, et al. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NOcGMP pathway and BDNF levels. Brain Research Bulletin 2014; 104:19–26.
19
Wang J, Fernández AE, Tiano S, Huang J, Floyd E, Poulev A, Ribnicky D, Pasinetti GM. An extract of Artemisia dracunculus L. promotes psychological resilience in a mouse model of depression. Oxidative Medicine and Cellular Longevity 2018.
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Jang D, Elfenbein HA. Menstrual cycle effects on mental health outcomes: a meta-analysis. Archives of Suicide Research 2018; 20: 1–21.
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Wang P, Liu C, Liu L, Zhang X, Ren B, Li B. The Antidepressant-like Effects of Estrogen-mediated Ghrelin. Current Neuropharmacology 2015; 13:524–35.
22
Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nature Reviews Immunology 2016;16(1):22-34.
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Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016;22(3):238-49.
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Liu Y, Huang C, Ceng C, Zhan H, Zheng D, Han W. Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia. Lipids in Health and Disease 2014; 13:115.
25
Shahraki MR, Mirshekari H, Samadi Z, Shahraki AR, Shahraki E. Effects of Artemisia dracunculus aqueous extract on blood sugar, serum insulin, triglyceride and liver enzymes in fructose drinking water male rats. Zahedan Journal of Research in Medical Sciences 2017;19(2):1-5.
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Antunes MS, Goes AT, Boeira SP, Prigol M, Jesse CR. Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice. Nutrition 2014; 104:19–26.
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33
ORIGINAL_ARTICLE
Tobacco carcinogen-induced alterations in expression of cellular stress response genes in lung of Wistar rats and the effect of exercise training
Objective: Present study investigated the effect of tobacco-specific carcinogen, nicotine-derived nitrosamine ketone (NNK), on the expression of cellular stress response genes in lung tissue of Wistar rats. Moreover, the effect of exercise training on alterations of these genes in exposed rats was investigated.
Materials and Methods: A total of 30 healthy Wistar rats were obtained and divided into the following group: (1) Control (CON), (2) NNK exposure (NNK, once a week / 12.5 mg per kg body mass for 12 weeks), and NNK + swimming training (NNK+ST, received NNK exposure + 25-60 min of aerobic swimming training / 5 days per week for 12 weeks). The mRNA expression level of nuclear factor kappa-B (NF-κB), forkhead box protein O3 (FOXO3), and Sirtuin-1 (Sirt-1) were determined in lung tissue by the quantitative real-time PCR.
Results: The NNK exposure resulted in a significant reduction in mRNA expression of the NF-κB and FOXO3 (P=0.0001 and P=0.005, respectively), as well as a significant increment in mRNA expression of Sirt-1 (P=0.001) comparing to the CON group. Moreover, the ST in rats under NNK treatment led to a significant reduction in mRNA expression of NF-κB (P=0.0001), but it did not have any significant effect on mRNA expression of FOXO3 and Sirt-1 (P>0.05) comparing to the NNK group.
Conclusion: These findings indicate that NNK exposure can lead to adverse alterations in the expression of cellular stress response genes in the lung tissue of Wistar rats and exercise training may not have any favorable effect on the expression of these genes in rats under NNK treatment.
https://jbcp.shahed.ac.ir/article_3459_5aca3445e5cf3bd9101a6eb1aea48276.pdf
2021-12-30
42
48
10.22070/jbcp.2021.14817.1147
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Cell Stress
Pulmonary
Swimming training
Maryam
Khalesi
mk.khalesi@gmail.com
1
Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, Iran
LEAD_AUTHOR
Shadmehr
Mirdar
shadmehr.mirdar@gmail.com
2
Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
AUTHOR
Ali
Samadi
ali.samadi.62@gmail.com
3
Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, Iran
AUTHOR
Vancou Neves Cruz J, Santana de Oliveira M, Gomes Silva S, Pedro da Silva Souza Filho A, Santiago Pereira D, Lima e Lima AH, et al. Insight into the interaction mechanism of nicotine, NNK, and NNN with cytochrome P450 2A13 based on molecular dynamics simulation. Journal of Chemical Information and Modeling 2019; 60(2):766-76.
1
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ORIGINAL_ARTICLE
The effect of paeonol on motor deficits and depressive and anxiety-like behavior in cuprizone-induced model of multiple sclerosis
Background and Objective: Patients with multiple sclerosis (MS) exhibit varying degrees of motor deficits, anxiety, and depression. Chronic oral cuprizone through evoking demyelination process is generally used to induce a model of MS to assess potential efficacy of promising therapeutics. Paeonol is a phenol compound with beneficial anti-inflammatory and protective effects. This study was conducted to investigate the effect of paeonol on motor deficits and depressive and anxiety-like behavior using open field, elevated plus maze, and tail suspension test in C57Bl/6 mice.Materials and Methods: Mice received oral cuprizone at a dose of 400 mg/kg for 6 weeks and paeonol was given orally at doses of 25 or 100 mg/kg/day from the second week for next five weeks. To assess motor function and depressive and anxiety-like behavior, open field task, tail suspension test (TST), and elevated-plus maze (EPM) test were used, respectively. Data were analyzed by one-way ANOVA and Tukey post-test with significance level < 0.05.Results: Paeonol administration to cuprizone group at the higher dose of 100 mg/kg improved locomotor activity and motor coordination as was evident by higher line crossing and an increase in the spent time in the center. In addition, paeonol treatment of cuprizone group significantly reduced spent time in the open arms of elevated-plus maze and also decreased immobility time in tail suspension task.Conclusion: This study showed reversal effects of paeonol regarding motor deficits and depressive and anxiety-like behavior in cuprizone-induced model of MS.
https://jbcp.shahed.ac.ir/article_3461_2211ad7c5ebe11aa1c39959130779f13.pdf
2021-12-30
49
54
10.22070/jbcp.2021.14744.1146
Cuprizone
Paeonol
Motor deficits
anxiety
Depression
Soosan
Pourmohammadi
pourmohammadis1381@yahoo.com
1
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran
AUTHOR
Zahra
Kiasalari
kiasalari@shahed.ac.ir
2
Neurophysiology Research Center, Shahed University, Tehran, Iran
AUTHOR
Mohsen
Khalili
najafabady@yahoo.com
3
Neurophysiology Research Center, Shahed University, Tehran, Iran
AUTHOR
Mehrdad
Roghani
mehjour@yahoo.com
4
Neurophysiology Research Center, Shahed University, Tehran, Iran
LEAD_AUTHOR
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