TY - JOUR ID - 147 TI - Protective Effect of Carvacrol in 6-hydroxydopamine Hemi-parkinsonian Rat Model JO - Journal of Basic and Clinical Pathophysiology JA - JBCP LA - en SN - 2322-1895 AU - Baluchnejadmojarad, tourandokht AU - Hassanshahi, Jalal AU - Roghani, Mehrdad AU - mansouri, Monireh AU - Raoufi, Safoura AD - TUMS, Tehran, Iran AD - Iran Univ Med. Sci AD - Shahed AD - IUMS Y1 - 2014 PY - 2014 VL - 2 IS - 2 SP - 29 EP - 34 KW - Carvacrol 6-hydroxydopamine Parkinson’s disease DO - N2 - Background and Objective: A huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in Parkinson’s disease (PD). Polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalities in an animal model of PD. Materials and Methods: In this study, unilateral intrastriatal 6-hydroxydopamine injected rats were daily pretreated with carvacrol (10 mg/kg) started three days before the surgery. Apomorphine-induced rotations and level of stress oxidative markers in the midbrain were assessed after 2 weeks. Results: Carvacrol administration lessened the rotation number in lesioned rats. Also, carvacrol decreased the 6-OHDA-induced malondialdehyde and nitrite level and intensified the antioxidant enzyme catalase, indicative of a protective effect against lipid peroxidation and free radicals synthesis. Conclusion: In summary, carvacrol shows a protective effect against 6-OHDA neurotoxicity, partly through attenuating oxidative stress.  UR - https://jbcp.shahed.ac.ir/article_147.html L1 - https://jbcp.shahed.ac.ir/article_147_dbb0c5b8634f38add50175b24be435d6.pdf ER -