TY - JOUR ID - 226 TI - Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation JO - Journal of Basic and Clinical Pathophysiology JA - JBCP LA - en SN - 2322-1895 AU - Narenjkar, Jamshid AU - Abyar, Zeinab AU - Roghani, Mehrdad AD - Department of Pharmacology, School of Medicine, Shahed University, Tehran, Iran AD - School of Medicine, Shahed University, Tehran, Iran AD - Neurophysiology Research Center, Shahed University, Tehran, Iran Y1 - 2015 PY - 2015 VL - 3 IS - 2 SP - 13 EP - 18 KW - Curcumin KW - Diabetes mellitus KW - Anti-nociceptive KW - Formalin test KW - Hot tail immersion test KW - Paw pressure test KW - Lipid peroxidation KW - Inflammation DO - 10.22070/jbcp.2015.226 N2 - Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. Materials and Methods: This study was conducted on 40 male rats that were divided into control, curcumin-treated control, diabetic, and curcumin-treated diabetic groups. The treatment groups received i.p. administration of curcumin at a dose of 50 mg/kg for 4 weeks. Finally, hyperalgesia were assessed using standard tests. Meanwhile, serum MDA and TNFa level was also measured. Results: Curcumin treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (pConclusion: Chronic administration of curcumin has anti-nociceptive property, partly via attenuation of lipid peroxidation and inflammatory processes. UR - https://jbcp.shahed.ac.ir/article_226.html L1 - https://jbcp.shahed.ac.ir/article_226_bd1ededd585cb22c790fffde293bb498.pdf ER -