TY - JOUR ID - 228 TI - Phytic Acid Mitigates Motor Asymmetry in Male Rat with Unilateral 6-Hydroxydopamine Striatal Lesion JO - Journal of Basic and Clinical Pathophysiology JA - JBCP LA - en SN - 2322-1895 AU - Rahmati, Batool AU - Khalili, Mohsen AU - Hamoleh-Shalali, Zohreh AU - Roghani, Mehrdad AU - Baluchnejadmojarad, Tourandokht AD - Neurophysiology Research Center, Shahed University, Tehran, Iran AD - School of Medicine, Shahed University, Tehran, Iran AD - Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Y1 - 2015 PY - 2015 VL - 3 IS - 2 SP - 25 EP - 28 KW - Phytic acid KW - Parkinson’s disease KW - 6-hydroxydopamine KW - Motor asymmetry DO - 10.22070/jbcp.2015.228 N2 - Background and Objective: Parkinson's disease (PD) is a movement disorder with debilitating symptoms. Available treatments for PD mainly include its symptomatic relief with no prevention of its progression. Due to the iron-chelating and antioxidant effect of phytic acid (PA), this study was conducted to assess its protective effect in 6-hydroxydopamine-induced model of PD in rat. Materials and Methods: Unilateral intrastriatal 6-OHDA-lesioned rats were daily pretreated with PA p.o. at a dose of 100 mg/kg for three days till 1 h pre-surgery. Apomorphine-induced rotations were counted at 1st week post-surgery. Results: A significant contralateral rotational behavior was observed in 6-OHDA-lesioned rats (pConclusion: These findings imply that pre-lesion PA treatment could attenuate motor asymmetry in experimental model of PD and this may be of benefit in lessening motor derangements in afflicted patients.  UR - https://jbcp.shahed.ac.ir/article_228.html L1 - https://jbcp.shahed.ac.ir/article_228_bcabd8d43bb0e62cd165eaebd3953a7d.pdf ER -