TY - JOUR ID - 539 TI - The Effect of Hepatocyte Growth Factor on Learning and Memory Abilities in a Rat Model of Kainate-Induced Epilepsy JO - Journal of Basic and Clinical Pathophysiology JA - JBCP LA - en SN - 2322-1895 AU - Jamali-raoufi, Nida AU - Haghani, Sobhan AU - Roghani, Mehrdad AU - Fahanik-Babaei, Javad AU - Baluchnejadmojarad, tourandokht AD - IUMS AD - Iran Univ Med. Sci. AD - Shahed Univ. AD - Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - TUMS, Tehran, Iran Y1 - 2017 PY - 2017 VL - 5 IS - 2 SP - 15 EP - 20 KW - Kainic acid KW - HGF KW - Passive avoidance KW - Y maze DO - 10.22070/jbcp.2017.2541.1079 N2 - Background and Objective: Epilepsy as a chronic neurological disorder causes inherent seizures and learning and memory failure. Since there is no acceptable control of seizures in some patients with the current recommended drug therapy, new medications with different mechanisms of action are needed. Here, the beneficial effect of hepatocyte growth factor (HGF) was evaluated in an experimental model of temporal lobe epilepsy in male rats. Materials and Methods: In the present study, effects of intracerebroventricular administration of HGF (6 µg) thirty minutes before intrahippocampal injection of kainic acid (4 µg) on spontaneous seizures and learning and memory impairment were assessed in rats. As positive control group, valproic acid (200 mg/kg) was injected intraperitoneally. Results: Behavior data showed that the kainate rats exhibited spontaneous seizures, lower spontaneous alternation score in Y-maze task (p Conclusion: This study revealed that HGF administration to kainate-injected rats attenuates seizure scores and improves learning and memory. UR - https://jbcp.shahed.ac.ir/article_539.html L1 - https://jbcp.shahed.ac.ir/article_539_ce564aa00db7c08a3f53af5e7def5fcb.pdf ER -