TY - JOUR ID - 7 TI - Soybean feeding improves vascular dysfunction and atte-nuates oxidative stress in streptozotocin-diabetic rats JO - Journal of Basic and Clinical Pathophysiology JA - JBCP LA - en SN - 2322-1895 AU - Baluchnejadmojarad, Tourandokht AU - Roghani, mehrdad AU - Roghani Dehkordi, Farshad AD - Physiology AD - AD - Cardiology Y1 - 2012 PY - 2012 VL - 1 IS - 1 SP - 37 EP - 45 KW - Key Words Soybean Diabetes mellitus Streptozotocin Aorta Nitric oxide Oxidative stress DO - N2 - Background and Objective: In this research, the effect of chronic dietary soybean aqueous extract on aortic reactivity of streptozotocin (STZ)-diabetic rats was investigated. Materials and Methods: STZ-diabetic rats were treated with soybean aqueous extract for two months after diabetes induction. Contractile reactivity to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh) were obtained from aortic rings and involved mechanisms were investigated. Results: Maximum contractile response of endothelium-intact rings to PE was significantly lower in soybean extract-treated diabetics relative to control diabetics (pConclusion: Chronic dietary treatment with soybean extract of diabetic rats attenuated some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and attenuation of oxidative stress in aortic tissue. UR - https://jbcp.shahed.ac.ir/article_7.html L1 - https://jbcp.shahed.ac.ir/article_7_c0bd0488830a00fa23b3f817d4467be7.pdf ER -