Shahed University Journal of Basic and Clinical Pathophysiology 2322-1895 13 1 2025 02 25 Evaluation of the anti-depressant effect of Melissa officinalis along with electroshock therapy in male rat 36 43 4719 10.22070/jbcp.2024.19834.1188 EN Hakimeh-Sadat Karimi Department of Physiology, School of Medicine, Shahed University, Tehran, Iran Hasti Jabbari Attending Gynecologist and Obstetrician at Isfahan University of Medical Science, Isfahan, Iran Mohsen Khalili Neurophysiology Research Center, Shahed University, Tehran, Iran Journal Article 2024 11 27 Background and Objective: Depression is a chronic disease with a high prevalence in the world and electroconvulsive therapy (ECT) as well as M. officinalis treatment are effective and less complicated methods in its treatment. Considering the side effects of electroshock therapy, in this study, the antidepressant effect of M. officinalis plant along with electroshock therapy on the behavioral and biochemical parameters of depressed animals were investigated. Materials and Methods: For this purpose, 56 male rats were divided into seven groups: 1- control, 2- depressed, 3- ECT, 4 and 5- treatment with M. officinalis at doses of 600 and 1000 mg/kg and 6 and 7- ECT+ M. officinalis at doses of 600 and 1000 mg/kg. Chronic unpredictable mild stress (CUMS) method was used to induce depression and finally the behavioral parameters of depression and oxidative stress biomarkers of the brain were evaluated. Results: In the ECT+M. officinalis treatment groups, the parameters of sucrose consumption, swimming and moving time in the open box and settling in the open arm of the elevated maze significantly increased (P<0.05). Also, MDA and NO were considerably decreased (P<0.05) and GSH, CAT and SOD were markedly increased (P<0.05). Conclusion: In general, our study showed that the consumption of the M. officinalis combined with ECT is quite effective in modulating the behavioral parameters and oxidative stress factors in depressive rats.

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