Shahed University Journal of Basic and Clinical Pathophysiology 2322-1895 14 2 2026 01 01 Examining the relationship between response threshold to electrical stimulation and sensitivity to pentylenetetrazol kindling in male rats 13 18 4927 10.22070/jbcp.2025.19696.1186 EN Nastaran Roshd-Rashidi Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Nahid Khodayari Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. Mohammad Reza Palizvan Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences. 0000-0001-7655-944X Journal Article 2024 10 13 Background and aim<br />Previous studies have demonstrated that foot electrical stimulation has the potential to inhibit kindling development in rats. However, it remains unclear whether there is a relationship between the sensitivity to electrical stimulation and its inhibitory effect on kindling. Therefore, the aim of this study is to investigate the correlation between chemical kindling and the electrical properties of the rat's paw. <br />Methods<br />Thirty-two male Westar rats were divided into three groups: control, 24 hours after kindling, and 60 days after kindling. PTZ kindling was induced by injecting PTZ (37.5 mg/kg). Response threshold to electrical stimulation and paw electrical resistance were measured in three groups. <br />Results<br />The results showed that there is a positive correlation between stage 5 duration and response threshold to electrical stimulation (p<0.05) and a negative correlation between stage 5 latency and the response threshold to electrical stimulation (p<0.050. Measuring the paw resistance showed that while in the control rats, there was no significant correlation between the response threshold to electrical stimulation and the plantar electrical resistance, in rats that had 60 days passed since their chemical kindling, there was a significant (p<0.05) and positive correlation.<br />Conclusion<br />The data suggest that rats with a higher threshold for electrical stimulation have a faster onset and longer duration of seizures induced by Pentylenetetrazole. Furthermore, comparing paw resistance revealed the potential impact of kindling on the relationship between paw electrical properties and seizure susceptibility. https://jbcp.shahed.ac.ir/article_4927_50d2d2262762648589b1943078712aa6.pdf