Journal of Basic and Clinical Pathophysiology

Journal of Basic and Clinical Pathophysiology

Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress

Document Type : Research Paper

Authors
tourandokht Baluchnejadmojarad 1
Nida Jamali-Raeufy 2
Mehrdad Roghani 3
Fahimeh zavvary 4
Samira Ramazi 4
Monireh Mansouri 4
1 TUMS, Tehran, Iran
2 IUMS
3 shahed
4 iums
Abstract
Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats.
Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-treated control, diabetic and salvialonic acid B-treated diabetic groups. Salvialonic acid B was administered at a dose of 10 mg/kg/day for 8 weeks. Assessment of learning and memory was performed by Y maze and passive avoidance tests. Moreover, oxidative stress marker malondialdehyde (MDA) was also measured.
Results: The results showed that in diabetic rats, alternation score in Y maze and retention and recall in passive avoidance test decreased in comparison with control rats (pConclusion: Taken together, these results show that salvialonic acid B could improve learning and memory deficits in STZ-diabetic rats by reduction of lipid peroxidation.
Keywords
Salvialonic acid B Learning and memory Streptozotocin