Journal of Basic and Clinical Pathophysiology

Journal of Basic and Clinical Pathophysiology

Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation

Document Type : Research Paper

Authors
Jamshid Narenjkar 1
Zeinab Abyar 2
Mehrdad Roghani 3
1 Department of Pharmacology, School of Medicine, Shahed University, Tehran, Iran
2 School of Medicine, Shahed University, Tehran, Iran
3 Neurophysiology Research Center, Shahed University, Tehran, Iran
10.22070/jbcp.2015.226
Abstract
Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests.
Materials and Methods: This study was conducted on 40 male rats that were divided into control, curcumin-treated control, diabetic, and curcumin-treated diabetic groups. The treatment groups received i.p. administration of curcumin at a dose of 50 mg/kg for 4 weeks. Finally, hyperalgesia were assessed using standard tests. Meanwhile, serum MDA and TNFa level was also measured.
Results: Curcumin treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (pConclusion: Chronic administration of curcumin has anti-nociceptive property, partly via attenuation of lipid peroxidation and inflammatory processes.
Keywords
Curcumin
Diabetes mellitus
Anti-nociceptive
Formalin test
Hot tail immersion test
Paw pressure test
Lipid peroxidation
Inflammation