Phytic Acid Mitigates Motor Asymmetry in Male Rat with Unilateral 6-Hydroxydopamine Striatal Lesion

Rahmati, Batool; Khalili, Mohsen; Hamoleh-Shalali, Zohreh; Roghani, Mehrdad; Baluchnejadmojarad, Tourandokht

doi:10.22070/jbcp.2015.228

Phytic Acid Mitigates Motor Asymmetry in Male Rat with Unilateral 6-Hydroxydopamine Striatal Lesion

Document Type : Research Paper

Authors

Batool Rahmati ¹

Mohsen Khalili ¹

Zohreh Hamoleh-Shalali ²

Mehrdad Roghani ¹

Tourandokht Baluchnejadmojarad ³

¹ Neurophysiology Research Center, Shahed University, Tehran, Iran

² School of Medicine, Shahed University, Tehran, Iran

³ Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

10.22070/jbcp.2015.228

Abstract

Background and Objective: Parkinson's disease (PD) is a movement disorder with debilitating symptoms. Available treatments for PD mainly include its symptomatic relief with no prevention of its progression. Due to the iron-chelating and antioxidant effect of phytic acid (PA), this study was conducted to assess its protective effect in 6-hydroxydopamine-induced model of PD in rat.
Materials and Methods: Unilateral intrastriatal 6-OHDA-lesioned rats were daily pretreated with PA p.o. at a dose of 100 mg/kg for three days till 1 h pre-surgery. Apomorphine-induced rotations were counted at 1^st week post-surgery.
Results: A significant contralateral rotational behavior was observed in 6-OHDA-lesioned rats (pConclusion: These findings imply that pre-lesion PA treatment could attenuate motor asymmetry in experimental model of PD and this may be of benefit in lessening motor derangements in afflicted patients.

Keywords

Phytic acid

Parkinson’s disease

6-hydroxydopamine

Motor asymmetry