Journal of Basic and Clinical Pathophysiology

Journal of Basic and Clinical Pathophysiology

The extraordinary efficacy of platelet rich fibrin membrane on fungal infections of nails in a human model

Document Type : Research Paper

Authors
Mahdieh Ghiasi 1
Mohammad Bigdello 2
Amirali Hamidieh 3
1 Iranian Tissue Bank & Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Surgery, Qom University of Medical Sciences, Qom, Iran
3 Iranian Tissue Bank & Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
10.22070/jbcp.2021.15252.1152
Abstract
Background: Fungal infections of nail can occur in people with brittle and dry skin. This condition can lead to nail damage and infection that spread beyond your feet if you have a suppressed immune system due to medication, diabetes or other conditions. If the immune system is suppressed due to medication, diabetes or other conditions, they expand. Some patients do not respond appropriately to common treatments. The use of platelet rich fibrin membrane (PRF M) has been suggested as an alternative method for fungal infection of nail treatment due to their potential to release many kinds of growth factors and antifungal efficacy.
Materials and Methods: The PRF M sample was obtained from the patient with fungal nail infection. PRF M was harvested from peripheral blood by centrifuging immediately. Moreover, PRF M was expanded over the damaged area in flat form five times for three days. Pre-treatment and post-treatment were then analyzed by observation of fungal infection.
Results: Visual observation showed the positive effect of this technique on the patient's recovery. Hence, it can be deduced that autologous PRF M is a promising safe therapy for drug-resistant fungal infections.
Conclusion: The present clinical case report demonstrated that PRF M may be able to remove fungal infections in human.
Keywords
Platelet rich fibrin membranes
Fungal infection of nail
Antifungal efficacy
Regeneration
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Journal of Basic and Clinical Pathophysiology
Volume 9, Issue 2
November 2021
Pages 11-14