Metformin improves semen profile and hormonal levels in experimental varicocele in the rat

Document Type : Research Paper

Authors

1 Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran

10.22070/jbcp.2023.18013.1171

Abstract

Abstract
Objective: This study aimed to determine the effect of metformin (MET) on semen profile and hormonal levels in a model of varicocele in rats.
Materials and Methods: Sixty male Wistar rats were allocated into 5 treatment groups as control and varicocele groups. In groups 3-5, varicocele animals received MET (25, 50 and 100 mg/kg) for 42 days. At the end of the study, semen evaluations and serum testosterone and luteinizing hormone and follicle stimulating hormone levels were measured.
Results: Experimental varicocele significantly decreased total sperm count and sperm motility and increased non-motile sperms compared to the control group (p<0.05). Metformin administration (50 and 100 mg/kg) significantly increased total sperm count and sperm motility and decreased non-motile sperm as compared to the varicocele group (p<0.05). In addition, experimental varicocele significantly decreased testosterone and luteinizing hormone and follicle stimulating hormone levels as compared to the control group (p<0.05). Metformin administration (50 and 100 mg/kg) significantly increased testosterone and luteinizing hormone and follicle stimulating hormone levels as compared to the varicocele group (p<0.05).
Conclusion: These results suggested that metformin has positive role against varicocele in the rat.

Keywords


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