Aluminium chloride-induced Alzheimer's disease and inflammation in the male rat reproductive system

Document Type : Research Paper

Authors

Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran

Abstract

Background and Objective: The abundance of aluminium (Al) along with its widespread use by humans has caused problems such as Alzheimer's disease and inflammation. We investigated the inflammation of the reproductive system of Alzheimer's rat model induced by aluminium chloride (AlCl3: Abbreviated as Al) in drinking water.
Materials and Methods: Animals (200-250 g) were randomly divided into control and treatment groups with Al (10 and 50 mg/kg). They were studied for two to four weeks, during which they consumed tap water or water containing the desired volume concentration of the substance. Blood samples were taken from anesthetized animals and testicular tissue was studied with different staining methods. Serum levels of testosterone (T), LH, FSH, TNF-α and IL-1ß were analyzed. T receptor density was also studied by immunohistochemistry (IHC). The data were analyzed using analysis of variance (ANOVA).
Results: The destructive effect of Al on the testis tissue was very significant in comparison to the control, regardless of the dose and duration of use. T and TNF-α levels as well as T receptor density were decreased. However, the weight of the animals did not show significant changes during the study.
Conclusion: Al can cause inflammation of the reproductive system and disrupt the structure and function of the reproductive system of rats.

Keywords

References

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Journal of Basic and Clinical Pathophysiology
Volume 12, Issue 2
October 2024
Pages 1-10

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