The effects of Lavandula angustifolia Mill extract on status epilepticus and depression-like behavior induced by intrahippocampal kainic acid injection

Document Type : Research Paper

Authors

1 Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran

2 Department of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Department of Physiology, School of Medicine, Shahed University, Tehran, Iran

Abstract

Background and Objective: Temporal lobe epilepsy (TLE) is a chronic neurological disorder with recurrent seizures, leading to oxidative stress disturbance, hippocampal neuronal damage, and behavior impairment such as depression. Herbal medicines, such as Lavandula angustifolia Mill, have emerged as potential therapeutic agents for various diseases, including epilepsy and depression. This study investigated the protective effects of L. angustifolia Mill extract on a rat model of kainic acid (KA)-induced TLE, depressive-like behavior, and oxidative stress.
Materials and Methods: Sixty adult male Wistar rats (250 ± 50 g) were divided into five groups: (1) sham control, (2) sham extract, (3) KA, (4) extract-treated (400 mg/kg), and (5) valproic acid-treated (300mg/kg) epileptic groups (n=12). The extract and valproate were administered via oral gavage daily for 2 weeks before and 4 weeks after intrahippocampal KA injection. Status epilepticus (SE) parameters, depressive-like behavior, and oxidative stress markers were evaluated.
Results: Pretreatment with the extract reduced the onset latency of SE (65 ± 1.5 min), whereas valproic acid increased it (130 ± 2.5 min) compared to the KA group (96.4 ± 1.8 min). The duration of seizures in the extract-treated group (174.3 ± 1.5 min) was longer than in the KA (140.9 ± 1.7 min) and valproic acid-treated groups (102.5 ± 2.6 min). However, the extract reduced the mortality rate (18.75%) more effectively than valproate (31.25%), despite intensifying SE. Additionally, the extract prevented depressive-like behavior induced by epilepsy, reduced hippocampal malondialdehyde (MDA) levels, and enhanced superoxide dismutase (SOD) activity.
Conclusion: Although L. angustifolia Mill extract intensified SE, it reduced mortality rates and provided protection against depression, potentially through its antioxidant effects.

Keywords

References

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Journal of Basic and Clinical Pathophysiology
Volume 13, Issue 1 - Serial Number 1
February 2025
Pages 50-60

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