Investigation of the resistance of Acinetobactor baumanii strains isolated from Tehran’s hospital inpatients in terms of selected antibiotics

Document Type : Research Paper

Authors

1 Department of Medical Microbiology, Faculty of Medicine, Shahed University of Medical Sciences, Tehran, Iran

2 School of Medicine, Shahed University, Tehran, Iran

Abstract

Background and Objective: The presence of the resistant bacteria in different wards of hospitals and problems which are thereby made by these organisms in treating patients specify the necessity to identify this type of bacteria and their antibiotic resistance pattern.
Materials and Methods: In this cross-sectional study, the resistance related to 60 samples of the isolated Acintobacter baumanii was gathered from three different hospitals of Tehran and they were studied in relation to six new antibiotic groups. Antibiotic sensitivity of the selected samples were also measured based on the disk diffusion method, and then it was reviewed by the CLSI table. The studied data were finally examined using the software SPSS 16 and Reference tests.
Results: The study findings showed that piperacillin-tazobactam antibiotic has the minimum rate of sensitivity with 86.7% resistance, and with 30% resistance, a combination of ampicillin-sulbactam is of the maximum sensitivity.
Conclusion: In this study, strains isolated from the patients showed a high resistance as compared to three antibiotics, and they were placed in species resisted to some drugs. Treating such infections can be considered as a great challenge to physicians.

Keywords


  1. Struelens MJ, Carlier E, Maes N, Serruys E, Quint WG, van Belkum A. Nosocomial colonization and infection with Multidrug-resistant t Acinetobacter baumannii: Outbreak delineation using DNA macro restriction analysis and PCR-fingerprinting. Journal of Hospital Infection 1993; 25:15–32.
  2. Centers for Disease Control. Overview of Drug-resistant Acinetobacter Infections in Healthcare Settings. Centers for Disease Control and Prevention. Available at: www.cdc.gov/ncidod/dhqp/ar_acinetobacter.html. Accessed October 26, 2009.
  3. Towner KJ. Acinetobacter: An old friend, but a new enemy. Journal of Hospital Infection 2009; 73:355–363.
  4. Davis KA, Moran KA, McAllister CK, Gray PJ. Multidrug-resistant Acinetobacter extremity infections in soldiers. Emerging Infectious Diseases journal 2005; 11:1218–1224.
  5. Oncul O, Keskin O, Acar HV, Kuçukardali Y, Evrenkaya R, Atasoyu EM, et al. Hospital-acquired infections following the 1999 Marmara earthquake. Journal of Hospital Infection 2002; 51:47–51.
  6. Young LS, Sabel AL, Price CS. Epidemiologic, clinical, and economic evaluation of an outbreak of clonal Multidrug-resistant Acinetobacter baumannii infection in a surgical intensive care unit. Infection Control & Hospital Epidemiology 2007; 28:1247–1254.
  7. Van Looveren M, Goossens H; ARPAC Steering Group. Antimicrobial resistance of Acinetobacter spp. in Europe. Clinical Microbiology and Infection 2004; 10:684–704.
  8. Ardabili A, Azimi L, Mohammadzaliqi H, Olaia P, Beheshti M. Determination of resistance pattern of Acinetobacter baumannii isolated from wound burn patients hospitalized in Motahari Hospital of Tehran Journal of Zanjan University of Medical Sciences 2012; 83(20): 112-119
  9. Doi Y, Murray GL, Peleg AY. Acinetobacter baumannii: Evolution of Antimicrobial Resistance-Treatment Options. Seminar Respiratory Critical Care Medicine 2015; 36(1):85-98.
  10. Gerald L, Mandell J. Principles and practices of infection disease. 8th edition 2010; Elsevier, Churchill, Livingstone.
  11. Kamalbeik S, Talaie H, Mahdavinejad A. Multidrug-resistant Acinetobacter baumannii infection in intensive care unit patients in a hospital with building construction: is there an association? Korean Journal of Anesthesiology 2014; 66(4): 295-299.
  12. Mirnezhad R, Mostofi S, Masjedian F. Investigating the role of class II integron in the antibiotic susceptibility pattern of Acinetobacter baumannii strains. Journal of Hamadan University of Medical Sciences 2011;22-28
  13. Percin D, Akyol S, Kalin G, In vitro synergism of combinations of colistin with selected antibiotics against colistin-resistant Acinetobacter baumannii. GMS Hygiene and Infection Control 2014; 9(2).
  14. Van TD, Dinh QD, Vu PD. Antibiotic susceptibility and molecular epidemiology of Acinetobacter calcoaceticus-baumannii complex strains isolated from a referral hospital in northern Vietnam. The Journal of Global Antimicrobial Resistance 2014; 2(4):318-21.
  15. Doi Y, Murray GL, Peleg AY. Acinetobacter baumannii: Evolution of Antimicrobial Resistance-Treatment Options. Seminar Respiratory Critical Care Medicine 2015; 36(1):85-98.
  16. Ozdem B, gurelic FC, Celikbilen N, Balikci H, Acikgoz ZC. Antibiotic resistance profiles of Acinetobacter species isolated from several clinical samples between 2007-2010. Mikrobiyoloji Bulteni 2011; 45(3):526-34