• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter Telegram
Journal of Basic and Clinical Pathophysiology
Articles in Press
Current Issue
Journal Archive
Volume Volume 6 (2018)
Volume Volume 5 (2016-2017)
Volume Volume 4 (2015-2016)
Volume Volume 3 (2014-2015)
Volume Volume 2 (2013-2014)
Issue Issue 2
Issue Issue 1
Volume Volume 1 (2012-2013)
Roghani Dehkordi, F., Enteshari, A. (2013). The in vitro effect of Melissa officinalis aqueous extract on aortic reactivity in rats with subchronic diabetes. Journal of Basic and Clinical Pathophysiology, 2(1), 44-49.
Farshad Roghani Dehkordi; Arezou Enteshari. "The in vitro effect of Melissa officinalis aqueous extract on aortic reactivity in rats with subchronic diabetes". Journal of Basic and Clinical Pathophysiology, 2, 1, 2013, 44-49.
Roghani Dehkordi, F., Enteshari, A. (2013). 'The in vitro effect of Melissa officinalis aqueous extract on aortic reactivity in rats with subchronic diabetes', Journal of Basic and Clinical Pathophysiology, 2(1), pp. 44-49.
Roghani Dehkordi, F., Enteshari, A. The in vitro effect of Melissa officinalis aqueous extract on aortic reactivity in rats with subchronic diabetes. Journal of Basic and Clinical Pathophysiology, 2013; 2(1): 44-49.

The in vitro effect of Melissa officinalis aqueous extract on aortic reactivity in rats with subchronic diabetes

Article 8, Volume 2, Issue 1, Summer and Autumn 2013, Page 44-49  XML PDF (226 K)
Document Type: Research Paper
Authors
Farshad Roghani Dehkordi 1; Arezou Enteshari2
1Isfahan Univ Med. Sci.
2Isfahan Univ. Med. Sci.
Abstract
Abstract
Background and Objective: Vascular abnormality and dysfunction plays an important role in the pathogenesis of vascular disease in diabetic state. In this study, we aimed to investigate whether an in vitro exposure of endothelium-intact aortic rings to Melissa officinalis (lemon balm, MO) aqueous extract could have a beneficial effect in rats with subchronic diabetes.
Materials and Methods: Diabetes was induced with a single dose of intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). After one month, reactivity of isolated endothelium-intact aortic rings to KCl and phenylephrine (PE) in the absence and presence of blockers of nitric oxide synthase (L-NAME) and prostaglandin synthesis pathway (indomethacin) in addition to the role of extracellular calcium was evaluated in the presence of MO extract in a cumulative manner.
Results: After 1 month, addition of MO extract (at a concentration range of 0.2-1 mg/ml) caused a significant concentration-dependent relaxation of phenylephrine (PE) and not KCl-preconstricted rings in both control and diabetic groups with a significant inter-group difference of pConclusion: These findings show that MO aqueous extract could relax the PE-preconstricted rings of aorta in STZ-diabetic rats through a nitric oxide pathway and prostaglandin pathway does not have a significant role and this extract could not affect the release of calcium from intracellular stores.
Keywords
Keywords: Melissa officinalis; Diabetes mellitus; Streptozotocin; Aorta; Vasorelaxation
Statistics
Article View: 1,569
PDF Download: 1,398
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by sinaweb.