Baluchnejadmojarad, T., Jamali-Raeufy, N., Roghani, M., zavvary, F., Ramazi, S., Mansouri, M. (2014). Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress. Journal of Basic and Clinical Pathophysiology, 2(2), 43-50.
tourandokht Baluchnejadmojarad; Nida Jamali-Raeufy; Mehrdad Roghani; Fahimeh zavvary; Samira Ramazi; Monireh Mansouri. "Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress". Journal of Basic and Clinical Pathophysiology, 2, 2, 2014, 43-50.
Baluchnejadmojarad, T., Jamali-Raeufy, N., Roghani, M., zavvary, F., Ramazi, S., Mansouri, M. (2014). 'Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress', Journal of Basic and Clinical Pathophysiology, 2(2), pp. 43-50.
Baluchnejadmojarad, T., Jamali-Raeufy, N., Roghani, M., zavvary, F., Ramazi, S., Mansouri, M. Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress. Journal of Basic and Clinical Pathophysiology, 2014; 2(2): 43-50.
Administration of Salvianolic Acid B Attenuates Learning and Memory Deficits in Diabetic Rats: Involvement of Oxidative Stress
Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-treated control, diabetic and salvialonic acid B-treated diabetic groups. Salvialonic acid B was administered at a dose of 10 mg/kg/day for 8 weeks. Assessment of learning and memory was performed by Y maze and passive avoidance tests. Moreover, oxidative stress marker malondialdehyde (MDA) was also measured. Results: The results showed that in diabetic rats, alternation score in Y maze and retention and recall in passive avoidance test decreased in comparison with control rats (pConclusion: Taken together, these results show that salvialonic acid B could improve learning and memory deficits in STZ-diabetic rats by reduction of lipid peroxidation.
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