Association of Inflammatory Mediators with Coronary Artery Disease in Diabetic Patients

Document Type: Research Paper


Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


Background and Objectives: Coronary artery disease (CAD) is regarded as the leading cause of morbidity and mortality around the world. Diabetes mellitus (DM) is associated with the development of CAD and increased risk of morbidity and mortality. The goal of this study was to assess the association of tumor necrosis factorα (TNF-α) and high sensitivity C-reactive protein (hsCRP) with CAD severity in diabetic patients.
Materials & Methods: The cross-sectional protocol of this research was conducted on the referrals (n=81) of Chamran and Alzahra hospitals (Isfahan, Iran) in 2012. The severity of CAD was determined using angiographic findings and Gensini scoring system. TNF-α and hsCRP were measured in addition to some routine parameters. For statistical analysis, Chi-square test was used.
Results: Of the patients, 57 were male (70.3%) and 24 (29.6%) were female with a mean age of 54.2 years. In addition, a significant relationship was found out between the severity of CAD and level of hsCRP and TNFa (p<0.05-0.01).
Conclusion: Markers of inflammatory mediators like hsCRP and TNFa are strongly associated with CAD in diabetic patients that have clinically high prognostic value.