1Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Neurophysiology Research Center, Shahed University, Tehran, Iran
Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. L-dihydroxyphenylamine (L-DOPA) therapy is currently the gold standard maneuver for PD. Due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this agent on motor asymmetry induced by intrastriatal injection of 6-hydroxydopamine in the rat. Materials and Methods: In this experimental research, male Wistar rats (n=48) were equally divided into sham, sesamin20-treated sham, 6-hydroxydopamine (OHDA)-lesioned, sesamin10 and sesamin20-treated lesion groups, and sesamin20-treated lesion group receiving the estrogenic antagonist fulvestrant. Model of PD was induced by microinjecting 12.5 microgram of 6-OHDA dissolved in normal saline-ascorbate solution into the left striatum. Treated lesion groups received sesamin at doses of 10 or 20 mg/kg/day started one week till 1 h before the surgery. After 1 week, ipsilateral and contralateral rotations induced by apomorphine were counted and net scores were obtained. Results: In the 6-OHDA-lesioned group, the dopaminergic agonist apomorphine induced contralateral rotational behavior (PConclusion: Sesamin administration at doses of 10 and 20 mg/kg could reduce motor asymmetry and attenuate forced biased rotational behavior in 6-OHDA-induced model of PD and part of this effect is possibly via an estrogenic pathway.