Home Articles List Article Information
Journal of Basic and Clinical Pathophysiology
Journal Archive
Volume Volume 6 (2018)
Volume Volume 5 (2016-2017)
Volume Volume 4 (2015-2016)
Volume Volume 3 (2014-2015)
Volume Volume 2 (2013-2014)
Volume Volume 1 (2012-2013)
Roghani, M., Azimi, A., Aghajani, M. (2016). Antinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation. Journal of Basic and Clinical Pathophysiology, 4(2), 37-42. doi: 10.22070/jbcp.2016.371
Mehrdad Roghani; Armin Azimi; Marjan Aghajani. "Antinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation". Journal of Basic and Clinical Pathophysiology, 4, 2, 2016, 37-42. doi: 10.22070/jbcp.2016.371
Roghani, M., Azimi, A., Aghajani, M. (2016). 'Antinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation', Journal of Basic and Clinical Pathophysiology, 4(2), pp. 37-42. doi: 10.22070/jbcp.2016.371
Roghani, M., Azimi, A., Aghajani, M. Antinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation. Journal of Basic and Clinical Pathophysiology, 2016; 4(2): 37-42. doi: 10.22070/jbcp.2016.371

Antinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation

Article 7, Volume 4, Issue 2, Winter and Spring 2016, Page 37-42  XML PDF (576 K)
Document Type: Research Paper
DOI: 10.22070/jbcp.2016.371
Authors
Mehrdad Roghani 1; Armin Azimi2; Marjan Aghajani3
1Shahed Univ.
2shahed
3TUMS
Abstract
Background and Objective: Due to the presence of some evidence for anti-diabetic and antioxidant activity of Tribulus terrestris (TT), this study was designed to investigate the anti-nociceptive effect of TT in streptozotocin-diabetic rats using formalin test and hot tail immersion tests.
Materials and Methods: Rats were divided into control, TT-treated control, diabetic, sodium salicylate (SS)-treated diabetic (as positive control), and TT-treated diabetic groups. The treatment groups received oral administration of TT-mixed pelleted food (3%) for 5 weeks. Serum level of malondialdehyde (MDA) as a reliable marker of lipid peroxidation was also measured.
Results: TT treatment of diabetic rats reduced pain score only in chronic phase of the formalin test (pConclusion: Taken together, 5-week administration of TT could attenuate nociceptive score in chronic phase of formalin test in streptozotocin-induced experimental model of diabetes mellitus and has no significant effect on thermal pain threshold and part of its beneficial effect is exerted via attenuation of lipid peroxidation and possibly reduction of oxidative stress.
Keywords
Tribulus terrestris; Diabetes mellitus; Pain; Formalin test; Hot tail immersion test
References
  1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(5):1047-53.
  2. Sima AA, Sugimoto K. Experimental diabetic neuropathy: an update. Diabetologia 1999; 42: 773-88.
  3. van Dam PS. Oxidative stress and diabetic neuropathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metabolism Research and Reviews 2002;18(3):176-84.
  4. Arora MK, Singh UK. Molecular mechanisms in the pathogenesis of diabetic nephropathy: an update. Vascular Pharmacology 2013;58(4):259-71.
  5. Dorresteijn JA, Kriegsman DM, Valk GD. Complex interventions for preventing diabetic foot ulceration. The Cochrane Database of Systematic Reviews 2010(1):Cd007610.
  6. Griebeler ML, Tsapas A, Brito JP, Wang Z, Phung OJ, Montori VM, et al. Pharmacologic interventions for painful diabetic neuropathy: an umbrella systematic review and comparative effectiveness network meta-analysis (Protocol). Systematic Reviews 2012;1:61.
  7. Gao F, Zheng ZM. Animal models of diabetic neuropathic pain. Experimental and Clinical Endocrinology & Diabetes 2014;122(2):100-6.
  8. Gallagher HC, Gallagher RM, Butler M, Buggy DJ, Henman MC. Venlafaxine for neuropathic pain in adults. The Cochrane Database of Systematic Reviews 2015;8:Cd011091.
  9. Javed S, Petropoulos IN, Alam U, Malik RA. Treatment of painful diabetic neuropathy. Therapeutic Advances in Chronic Disease 2015;6(1):15-28.
  10. Amin A, Lotfy M, Shafiullah M, Adeghate E. The protective effect of Tribulus terrestris in diabetes. Annals of the New York Academy of Sciences 2006; 1084: 391-401.
  11. Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S. Phytopharmacological overview of Tribulus terrestris. Pharmacognosy Reviews 2014;8(15):45-51.
  12. Qureshi A, Naughton DP, Petroczi A. A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. Journal of Dietary Supplements 2014;11(1):64-79.
  13. Ranjithkumar R, Prathab Balaji S, Balaji B, Ramesh RV, Ramanathan M. Standardized Aqueous Tribulus terristris (nerunjil) extract attenuates hyperalgesia in experimentally induced diabetic neuropathic pain model: role of oxidative stress and inflammatory mediators. Phytotherapy Research 2013;27(11):1646-57.
  14. Raoufi S, Baluchnejadmojarad T, Roghani M, Ghazanfari T, Khojasteh F, Mansouri M. Antidiabetic potential of salvianolic acid B in multiple low-dose streptozotocin-induced diabetes. Pharmaceutical Biology 2015;53(12):1803-9.
  15. Baluchnejadmojarad T, Roghani M, Roghani-Dehkordi F. Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. Journal of Ethnopharmacology 2005;97(2):207-10.
  16. Mirshekar M, Roghani M, Khalili M, Baluchnejadmojarad T, Arab Moazzen S. Chronic oral pelargonidin alleviates streptozotocin-induced diabetic neuropathic hyperalgesia in rat: involvement of oxidative stress. Iranian Biomedical Journal 2010;14(1-2):33-9.
  17. Dobretsov M, Hastings SL, Stimers JR, Zhang JM. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. Journal of Neuroscience Methods 2001;110(1-2):9-15.
  18. Greig M, Tesfaye S, Selvarajah D, Wilkinson ID. Insights into the pathogenesis and treatment of painful diabetic neuropathy. Handbook of Clinical Neurology 2014;126:559-78.
  19. Lee-Kubli CA, Calcutt NA. Painful neuropathy: Mechanisms. Handbook of Clinical Neurology 2014;126:533-57.
  20. Shibata M, Ohkubo T, Takahashi H, Inoki R. Modified formalin test: characteristic biphasic pain response. Pain 1989;38(3):347-52.
  21. Rosland JH, Hunskaar S, Hole K. Diazepam attenuates morphine antinociception test-dependently in mice. Pharmacology & Toxicology 1990;66(5):382-6.
  22. Rosland JH, Tjolsen A, Maehle B, Hole K. The formalin test in mice: effect of formalin concentration. Pain 1990;42; 235-42.
  23. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of Tribulus Terrestris Extract on the Serum Glucose and Lipids of Women with Diabetes Mellitus. Iranian Journal of Medical Sciences 2016;41(3):S5. 
Statistics
Article View: 778
PDF Download: 601