Maternal serum levels of interleukin-6 and β-hCG in women with hyperemesis gravidarum in the first trimester of pregnancy

Document Type : Research Paper

Authors

1 Associate Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Shahed University, Tehran, Iran

2 Professor, Immunoregulation Research Center, Shahed University, Tehran, Iran

3 Assistant Professor, Proteomic Research Center, School of Paramedical Sciences, Shahid Beheshti University, Tehran, Iran

4 Faculty of Medicine, School of Medicine, Shahed University, Tehran, Iran

Abstract

Background and Objective: Hyperemesis gravidarum (HG) is defined as vomiting sufficiently severe to produce weight loss, dehydration, electrolyte abnormalities. Interleukin-6 (IL-6), a pro-inflammatory and trophoblast-derived cytokine has ability to induce trophoblasts to secrete human chorionic gonadotropin (hCG). The purpose of our study was to assay the level of IL-6 and β-hCG in serum of pregnant women suffering from HG during the first trimester of pregnancy and compare with gestational age-matched controls and normal non pregnant women.
Materials and Methods: Plasma concentrations of IL-6 and β-hCG were measured in 30 healthy non pregnant women and 30 women with HG, 30 pregnant women with nausea and vomiting of pregnancy (NVP) and 30 normal pregnant women, matched for age, parity and gestational age .
Results: Mean serum levels of β-hCG were higher in women with HG. There was a significant difference between the three groups (P Conclusion: IL-6 levels rise in women with HG and this could lead to higher levels of hCG seen in these patients. It appears that IL-6 does not have a primary role in etiology of HG.

Keywords

References

  1. Einarson TR, Piwko C, Koren G. Quantifying the global rates of nausea and vomiting of pregnancy: a meta-analysis. Journal of population therapeutics and clinical pharmacology 2013;20(2):e171-83.
  2. Herrell HE. Nausea and vomiting of pregnancy. American Family Physician. 2014 ;89(12):965-70.
  3. Matthews A, Haas DM, O'Mathúna DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. The Cochrane Database of Systematic Reviews. 2015; 8:9
  4. McCarthy FP, Lutomski JE, Greene RA. Hyperemesis gravidarum: current perspectives. International Journal of Women's Health. 2014; 5;6:719-25.
  5. Chan RL, Olshan AF, Savitz DA, Herring AH, Daniels JL, Peterson HB, Martin SL. Maternal influences on nausea and vomiting in early pregnancy. Maternal and Child Health Journal. 2011;15(1):122-7.
  6. Kameda T, Matsuzaki N, Sawai K, Okada T, Saji F, Matsuda T, Hirano T, Kishimoto T, Tanizawa O (1990) . Production of interleukin-6 by normal human trophoblast. Placenta 11: 205-213.
  7. Prins JR, Gomez-Lopez N, Robertson SA. Interleukin-6 in pregnancy and gestational disorders. Journal of Reproductive Immunology. 2012;95(1-2):1-14.
  8. Nishino E, Matsuzaki N, Masuhiro K, Kameda T, Taniguchi T, Takagi T, Saji F, Tanizawa O (1990). Trophoblast-derived interleukin-6 (IL-6) regulates human chorionic gonadotropin release through IL-6 receptor on human trophoblasts. The Journal of Clinical Endocrinology and Metabolism 71:436-444. 
  9. Yanushpolsky EH, Ozturk M, Polgar K, Berkowitz RS. Hill J A (1993). The effects of cytokines on human chorionic gonadotropin (hcG) production by a trophoblast cell Line. Journal of Reproductive Immunology. 25: 235-247.
  10. Niemeijer MN, Grooten IJ, Vos N, Bais JM, van der Post JA, Mol BW, Roseboom TJ, Leeflang MM, Painter RC. Diagnostic markers for hyperemesis gravidarum: a systematic review and meta analysis. The American Journal of Obstetrics and Gynecology. 2014;211(2).
  11. P.C. Tan, N.C. Tan, S.Z. Omar. Effect of high levels of human chorionic gonadotropin and estradiol on the severity of hyperemesis gravidarum.. Clinical Chemistry and Laboratory Medicine. 2009; 165–17.
  12. A.U. Derbent, F.F. Yanik, S. Simavli, et al. First trimester maternal serum PAPP-A and free beta-HCG levels in hyperemesis gravidarum. Prenatal Diagnosis.2011;450–453.
  13. N.K. Kuscu, Y. Yildirim, F. Koyuncu, A. Var, B.S. Uyanik. Interleukin-6 levels in hyperemesis gravidarum . Archives of Gynecology and Obstetrics.2003; 13–15.
  14. Kaplan PB, Gücer F, Sayin NC, Yüksel M, Yüce MA, Yardim T. Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy. Fertility and Sterility. 2003 ;79(3):498-502.
  15. Tunc SY, Agacayak E, Budak S, Tunc N, Icen MS, Findik FM, Ekinci A, Gul T.Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum. The Journal of Obstetrics and Gynaecology Research. 2016; 2.
  16. Derbent AU,Yanik FF, Simavli S, Atasoy L, Urün E, Kuşçu UE, Turhan NÖ. First trimester maternal serum PAPP-A and free β-HCG levels in hyperemesis gravidarum. Prenatal Diagnosis. 2011;31(5):450-3.
  17. Lee NM, Saha S. Nausea and vomiting of pregnancy. Gastroenterology Clinics of North America. 2011;40(2):309-34.
  18. Li Y, Matsuzaki N, Masuhiro K, Kameda T, Taniguchi T, Saji F, et al. Trophoblast-derived tumor necrosis factor-_ induces release of human chorionic gonadotropin using interleukin-6 (IL-6) and IL-6 receptor dependent system in the healthy human trophoblasts. Journal of Clinical Endocrinology & Metabolism.1992;74:184–91.
Journal of Basic and Clinical Pathophysiology
Volume 5, Issue 1
December 2016
Pages 13-18

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