Journal of Basic and Clinical Pathophysiology

Journal of Basic and Clinical Pathophysiology

Relationship between response threshold to electrical stimulation and sensitivity to pentylenetetrazol kindling in male rats

Document Type : Research Paper

Authors
Nastaran Roshd-Rashidi
Nahid khodayari
mohammad reza palizvan
Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
10.22070/jbcp.2025.19696.1186
Abstract
Background and Objective: Previous studies have demonstrated that foot electrical stimulation has the potential to inhibit kindling development in rats. However, it remains unclear whether there is a relationship between the sensitivity to electrical stimulation and its inhibitory effect on kindling. Therefore, the aim of this study was to investigate the correlation between chemical kindling and electrical properties of the rats’ paw.
Materials and Methods: Thirty-two male Wistar rats were divided into three groups; control, 24 hours after kindling and 60 days after kindling. Pentylenetetrazol (PTZ) kindling was induced by injecting PTZ (37.5 mg/kg). Response threshold to electrical stimulation and paw electrical resistance was measured in the three groups.
Results: The findings showed that there is a positive correlation between stage 5 duration and response threshold to electrical stimulation (p<0.05) and a negative correlation between stage 5 latency and the response threshold to electrical stimulation (p<0.05). Measuring the paw resistance showed that while in the control rats there was no significant correlation between the response threshold to electrical stimulation and the plantar electrical resistance, in rats that had 60 days passed since their chemical kindling, there was a significant and positive correlation (p<0.05).
Conclusion: The data suggest that rats that had a higher threshold for electrical stimulation have a faster, onset and longer duration for seizures induced by PTZ. Furthermore, the comparison of paw resistance revealed the potential impact of kindling on the relationship between paw electrical properties and seizure susceptibility.
Keywords
Pentylenetetrazol kindling
Response threshold
electrical resistance
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Journal of Basic and Clinical Pathophysiology
Volume 14, Issue 2
January 2026
Pages 13-18