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Journal of Basic and Clinical Pathophysiology
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Narenjkar, J., Abyar, Z., Roghani, M. (2015). Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation. Journal of Basic and Clinical Pathophysiology, 3(2), 13-18. doi: 10.22070/jbcp.2015.226
Jamshid Narenjkar; Zeinab Abyar; Mehrdad Roghani. "Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation". Journal of Basic and Clinical Pathophysiology, 3, 2, 2015, 13-18. doi: 10.22070/jbcp.2015.226
Narenjkar, J., Abyar, Z., Roghani, M. (2015). 'Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation', Journal of Basic and Clinical Pathophysiology, 3(2), pp. 13-18. doi: 10.22070/jbcp.2015.226
Narenjkar, J., Abyar, Z., Roghani, M. Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation. Journal of Basic and Clinical Pathophysiology, 2015; 3(2): 13-18. doi: 10.22070/jbcp.2015.226

Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation

Article 4, Volume 3, Issue 2, Winter and Spring 2015, Page 13-18  XML PDF (410 K)
Document Type: Research Paper
DOI: 10.22070/jbcp.2015.226
Authors
Jamshid Narenjkar1; Zeinab Abyar2; Mehrdad Roghani 3
1Department of Pharmacology, School of Medicine, Shahed University, Tehran, Iran
2School of Medicine, Shahed University, Tehran, Iran
3Neurophysiology Research Center, Shahed University, Tehran, Iran
Abstract
Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests.
Materials and Methods: This study was conducted on 40 male rats that were divided into control, curcumin-treated control, diabetic, and curcumin-treated diabetic groups. The treatment groups received i.p. administration of curcumin at a dose of 50 mg/kg for 4 weeks. Finally, hyperalgesia were assessed using standard tests. Meanwhile, serum MDA and TNFa level was also measured.
Results: Curcumin treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (pConclusion: Chronic administration of curcumin has anti-nociceptive property, partly via attenuation of lipid peroxidation and inflammatory processes.
Keywords
Curcumin; Diabetes mellitus; Anti-nociceptive; Formalin test; Hot tail immersion test; Paw pressure test; Lipid peroxidation; Inflammation
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